A. Multi scatterplot showing pairwise comparisons of LFQ values for “Control”, “AlkK”, “AAV” and “SORT” groups. The data show replicates from three mice, n=3 for each experimental condition. “Control” indicates WT mice, “AlkK” refers to mice fed the amino acid exactly as in a SORT experiment. “AAV” indicates mice injected with hSyn1-SORTCAU AAV, exactly as for SORT, but with no AlkK addition. “SORT” indicates mice used for SORT-E. B. Pairwise calculated Pearson correlation coefficients between all samples and plotted as a heat map. C. Heat map with an average of Pearson correlation coefficients from replica pairwise comparisons within each group. D. Weight of mice before and after SORT, n=15.