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When pig organs will fly

Regulators, scientists and surgeons are preparing the groundwork for human trials of engineered pig organs—and industry is starting to take notice.

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References

  1. Wu, J. et al. Cell 168, 473–486.e15 (2017).

    Article  CAS  Google Scholar 

  2. Perkel, J.M. Nat. Biotechnol. 34, 3–4 (2016).

    Article  CAS  Google Scholar 

  3. Martens, G.R. et al. Transplantation 101, e86–e92 (2017).

    Article  CAS  Google Scholar 

  4. Kawai, T. et al. N. Engl. J. Med. 358, 353–361 (2008).

    Article  CAS  Google Scholar 

  5. Mohiuddin, M.M. et al. Nat. Commun. 7, 11138 (2016).

    Article  CAS  Google Scholar 

  6. Shah, J.A. et al. Am. J. Transplant. 17, 2178–2185 (2017).

    Article  CAS  Google Scholar 

  7. Iwase, H. et al. Xenotransplantation 24, e12293 (2017).

    Article  Google Scholar 

  8. Wynyard, S., Nathu, D., Garkavenko, O., Denner, J. & Elliott, R. Xenotransplantation 21, 309–323 (2014).

    Article  Google Scholar 

  9. Yang, L. et al. Science 350, 1101–1104 (2015).

    Article  CAS  Google Scholar 

  10. Niu, D. et al. Science 357, 1303–1307 (2017).

    Article  CAS  Google Scholar 

  11. Matsunari, H. et al. Proc. Natl. Acad. Sci. USA 110, 4557–4562 (2013).

    Article  CAS  Google Scholar 

  12. Yamaguchi, T. et al. Nature 542, 191–196 (2017).

    Article  CAS  Google Scholar 

  13. Kobayashi, T. et al. Cell 142, 787–799 (2010).

    Article  CAS  Google Scholar 

  14. Wu, J. et al. Nature 540, 51–59 (2016).

    Article  CAS  Google Scholar 

  15. Yang, Y. et al. Cell 169, 243–257.e25 (2017).

    Article  CAS  Google Scholar 

  16. Han, X. et al. Cell Stem Cell 12, 342–353 (2013).

    Article  CAS  Google Scholar 

  17. Mizuno, H., Akutsu, H. & Kato, K. Life Sci. Soc. Policy 11, 15 (2015).

    Article  Google Scholar 

  18. Gazzaniga, M. The Ethical Brain: The Science of Our Moral Dilemmas (HarperCollins, 2006).

    Google Scholar 

  19. Windrem, M.S. et al. Cell Stem Cell 21, 195–208.e6 (2017).

    Article  CAS  Google Scholar 

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Waltz, E. When pig organs will fly. Nat Biotechnol 35, 1133–1138 (2017). https://doi.org/10.1038/nbt.4027

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