Revisiting the Warnock rule

Nature Biotechnology volume 35, pages1029–1042(2017)Cite this article

Subjects

An Erratum to this article was published on 08 December 2017

This article has been updated

Is it time to reassess the 14-day rule for human embryo research?

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

Rent or Buy

All prices are NET prices.

Change history

  • 10 November 2017

    In the version of this article initially published, J.E. Lunshof's affiliation was given as “Center for Bioethics, Harvard Medical School, Boston, Massachusetts, USA”; the affiliation should have included her main affiliation at the University of Groningen and read, “Department of Genetics, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands, and Department of Genetics, Church laboratory, Harvard Medical School, Boston, Massachusetts, USA.” In addition, “Divinity School, University of Chicago,” should be “University of Chicago Divinity School.” The errors have been corrected in the HTML and PDF versions of the article.

References

  1. 1

    Warnock, M. et al. Report of the Committee of Inquiry into Human Fertilisation and Embryology (Her Majesty's Stationery Office, London, UK, 1984).

    Google Scholar 

  2. 2

    Shahbazi, M.N. Self-organization of the human embryo in the absence of maternal tissues. Nat. Cell. Biol. 18, 700–708 (2016).

    CAS  Article  Google Scholar 

  3. 3

    Deglincerti, A. et al. Self-organization of the in vitro attached human embryo. Nature 533, 251–254 (2016).

    CAS  Article  Google Scholar 

  4. 4

    Bedzhov, I. & Zernicka-Goetz, M. Self-organizing properties of mouse pluripotent cells initiate morphogenesis upon implantation. Cell 156, 1032–1044 (2014).

    CAS  Article  Google Scholar 

  5. 5

    Bedzhov, I., Leung, C.Y., Bialecka, M. & Zernicka-Goetz, M. In vitro culture of mouse blastocysts beyond the implantation stages. Nat. Protoc. 9, 2732–2739 (2014).

    CAS  Article  Google Scholar 

  6. 6

    Partridge, E. et al. An extra-uterine system to physiologically support the extreme premature lamb. Nat. Commun. 8, 15112 (2017).

    Article  Google Scholar 

  7. 7

    Nuffield Council on Bioethics. Human Embryo Culture http://nuffieldbioethics.org/wp-content/uploads/Human-Embryo-Culture-web-FINAL.pdf (Nuffield Council on Bioethics, 2017).

  8. 8

    Harrison, S.E., Sozen, B., Christodoulou, N., Kyprianou, C. & Zernicka-Goetz, M. Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro. Science 356, https://dx.doi.org/10.1126/science.aal1810 (2017).

  9. 9

    Hammond-Browning, N. Ethics, embryos, and evidence: a look back at Warnock. Med. Law Rev. 23, 588–619 (2015).

    Article  Google Scholar 

  10. 10

    Cavaliere, G. A 14-limit for bioethics: the debate over human embryo research. BMC Med. Eth. https://dx.doi.org/10.1186/s12910-017-0198-5 (2017).

  11. 11

    Warnock, M. Moral thinking and government policy: the Warnock Committee on Human Embryology. Milbank Mem. Fund Q. Health Soc. 63, 504–522 (1985).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

  1. School of Life Sciences, Center for Biology and Society and School for the Future of Innovation in Society, Arizona State University, Tempe, Arizona, USA

    J Benjamin Hurlbut

  2. Department of Bioethics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Insoo Hyun

  3. School of Public Policy, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA

    Aaron D Levine

  4. The Francis Crick Institute, London, UK

    Robin Lovell-Badge

  5. Department of Genetics, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands

    Jeantine E Lunshof

  6. Department of Genetics, Church laboratory, Harvard Medical School, Boston, Massachusetts, USA

    Jeantine E Lunshof

  7. Baker Institute Center for Health and Biosciences, Rice University, Houston, Texas, USA

    Kirstin R W Matthews

  8. Nuffield Council on Bioethics, London, UK

    Peter Mills

  9. Department of Reproductive Medicine, International Centre for Life, Newcastle upon Tyne, UK

    Alison Murdoch

  10. The Jackson Laboratory, Bar Harbor, Maine, USA

    Martin F Pera

  11. Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas, USA

    Christopher Thomas Scott

  12. The Human Fertilisation and Embryology Authority, London, UK

    Juliet Tizzard

  13. Honorary Fellow, Hertford College, University of Oxford, Catte Street, Oxford, UK

    Mary Warnock

  14. Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

    Magdalena Zernicka-Goetz

  15. The State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

    Qi Zhou

  16. University of Chicago Divinity School, Chicago, Illinois, USA

    Laurie Zoloth

Authors
  1. J Benjamin Hurlbut
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Insoo Hyun
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aaron D Levine
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Robin Lovell-Badge
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jeantine E Lunshof
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kirstin R W Matthews
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Peter Mills
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Alison Murdoch
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Martin F Pera
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Christopher Thomas Scott
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Juliet Tizzard
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Mary Warnock
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Magdalena Zernicka-Goetz
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Qi Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Laurie Zoloth
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hurlbut, J., Hyun, I., Levine, A. et al. Revisiting the Warnock rule. Nat Biotechnol 35, 1029–1042 (2017). https://doi.org/10.1038/nbt.4015

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing