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When replacement becomes reversion

Mitochondrial replacement therapy is being touted as a means of combating maternally inherited disease. But concerns are growing about mitochondrial reversion compromising cures. Steve Connor investigates.

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Figure 1: Mitochondrial replacement therapy comes in three forms.

Debbie Maizels/Springer Nature

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Connor, S. When replacement becomes reversion. Nat Biotechnol 35, 1012–1015 (2017). https://doi.org/10.1038/nbt.3996

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