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When replacement becomes reversion

Mitochondrial replacement therapy is being touted as a means of combating maternally inherited disease. But concerns are growing about mitochondrial reversion compromising cures. Steve Connor investigates.

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Figure 1: Mitochondrial replacement therapy comes in three forms.

Debbie Maizels/Springer Nature


  1. 1

    Zhang, J. et al. Reprod. Biomed. Online 34, 361–368 (2017).

    Article  Google Scholar 

  2. 2

    Greenfield, A. et al. Nat. Biotechnol. 35, 1059–1068 (2017).

    CAS  Article  Google Scholar 

  3. 3

    Yamada, M. et al. Cell Stem Cell 18, 749–754 (2016).

    CAS  Article  Google Scholar 

  4. 4

    Cohen, J., Scott, R., Schimmel, T., Levron, J. & Willadsen, S. Lancet 350, 186–187 (1997).

    CAS  Article  Google Scholar 

  5. 5

    Connor, S. The Independent (2014).

    Google Scholar 

  6. 6

    Barritt, J.A., Brenner, C.A., Malter, H.E. & Cohen, J. Hum. Reprod. 16, 513–516 (2001).

    CAS  Article  Google Scholar 

  7. 7

    Zhang, J. et al. Fertil. Steril. 80 Supplement 3, 56 (2003).

    Article  Google Scholar 

  8. 8

    Zhang, J. et al. Reprod. Bio. Online 33, 529–533 (2016).

    Article  Google Scholar 

  9. 9

    Connor, S. indy100 (2015).

    Google Scholar 

  10. 10

    Wolf, D.P. et al. EMBO J. 36, 2177–2181 (2017).

    CAS  Article  Google Scholar 

Download references

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Connor, S. When replacement becomes reversion. Nat Biotechnol 35, 1012–1015 (2017).

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