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Acknowledgements

Research supported by grant of the Ministry of Education and Science of the Russian Federation Number 14.W03.31.0005. Human melanoma SPX6730 and SPX8151 sample preparation supported by European Union's Horizon 2020 Research and Innovation Programme Number 633592 (to T.N. Schumacher). Foxp3yfpcre mice sample preparation supported by NIH/NCI Cancer Center Support Grant P30 CA008748 (to A.Y. Rudensky).

Author information

Author notes

    • Dmitriy A Bolotin
    • , Stanislav Poslavsky
    • , Alexey N Davydov
    •  & Felix E Frenkel

    These authors contributed equally to this work.

Affiliations

  1. MiLaboratory LLC, Skolkovo Innovation Center, Moscow, Russia.

    • Dmitriy A Bolotin
    • , Stanislav Poslavsky
    •  & Mikhail Shugay
  2. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

    • Dmitriy A Bolotin
    • , Ekaterina V Putintseva
    • , Anna S Obraztsova
    • , Mikhail Shugay
    •  & Dmitriy M Chudakov
  3. Pirogov Russian National Research Medical University, Moscow, Russia

    • Dmitriy A Bolotin
    • , Stanislav Poslavsky
    • , Mikhail Shugay
    •  & Dmitriy M Chudakov
  4. Central European Institute of Technology, Brno, Czech Republic.

    • Alexey N Davydov
    •  & Dmitriy M Chudakov
  5. BostonGene LLC, Lincoln, Massachusetts, USA.

    • Felix E Frenkel
    • , Olga I Zolotareva
    •  & Ravshan I Ataullakhanov
  6. Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    • Lorenzo Fanchi
    •  & Ton N Schumacher
  7. Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

    • Saskia Hemmers
    •  & Alexander Y Rudensky
  8. Centre for Genomic Regulation, The Barcelona Institute for Science and Technology, Barcelona, Spain

    • Ekaterina V Putintseva
  9. Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.

    • Anna S Obraztsova
  10. Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia.

    • Mikhail Shugay
    •  & Dmitriy M Chudakov
  11. Center for Data-Intensive Biomedicine and Biotechnology, Skolkovo Institute of Science and Technology, Moscow, Russia.

    • Mikhail Shugay
    •  & Dmitriy M Chudakov
  12. Institute of Immunology FMBA, Moscow, Russia.

    • Ravshan I Ataullakhanov
  13. Faculties for Physics and Biology, Lomonosov Moscow State University, Moscow, Russia.

    • Ravshan I Ataullakhanov
  14. Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

    • Alexander Y Rudensky

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Competing interests

MiLaboratory LLC develops MiXCR software and has exclusive rights for its commercial distribution

Corresponding author

Correspondence to Dmitriy M Chudakov.

Supplementary information

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    Supplementary Figures

    Supplementary Figures 1–4, Supplementary Tables 1–3 and 5,Supplementary Notes 1–3 and Supplementary Methods

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    Supplementary Table 4

    Dominant and hypermutating intratumorally produced Ig clones

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DOI

https://doi.org/10.1038/nbt.3979

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