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Antigen receptor repertoire profiling from RNA-seq data

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Figure 1: Sensitivity and specificity of extraction of TCR and immunoglobulin repertoires from tumor RNA-seq data.
Figure 2: Immune repertoire analysis in human melanoma and sorted mice T cells.


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Research supported by grant of the Ministry of Education and Science of the Russian Federation Number 14.W03.31.0005. Human melanoma SPX6730 and SPX8151 sample preparation supported by European Union's Horizon 2020 Research and Innovation Programme Number 633592 (to T.N. Schumacher). Foxp3yfpcre mice sample preparation supported by NIH/NCI Cancer Center Support Grant P30 CA008748 (to A.Y. Rudensky).

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Correspondence to Dmitriy M Chudakov.

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MiLaboratory LLC develops MiXCR software and has exclusive rights for its commercial distribution

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Supplementary Figures

Supplementary Figures 1–4, Supplementary Tables 1–3 and 5,Supplementary Notes 1–3 and Supplementary Methods (PDF 8248 kb)

Reporting Summary

Life sciences reporting summary (PDF 1295 kb)

Supplementary Table 4

Dominant and hypermutating intratumorally produced Ig clones (XLSX 27 kb)

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Bolotin, D., Poslavsky, S., Davydov, A. et al. Antigen receptor repertoire profiling from RNA-seq data. Nat Biotechnol 35, 908–911 (2017).

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