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Rules of the road for insect gene drive research and testing

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References

  1. Gantz, V.M. & Bier, E. Science 348, 442–444 (2015).

    Article  CAS  Google Scholar 

  2. Gantz, V.M. et al. Proc. Natl. Acad. Sci. USA 112, E6736–E6743 (2015).

    Article  CAS  Google Scholar 

  3. Hammond, A. et al. Nat. Biotechnol. 34, 78–83 (2016).

    Article  CAS  Google Scholar 

  4. National Academies of Science, Engineering, and Medicine. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values (The National Academies Press, 2016).

  5. Carter, S.R. & Friedman, R.M. Policy and Regulatory Issues for Gene Drives in Insects: Workshop Report (J. Craig Venter Institute, San Diego, CA, 2016). http://www.jcvi.org/cms/fileadmin/site/research/projects/gene-drive-workshop/report-complete.pdf

    Google Scholar 

  6. Akbari, O.S. et al. Science 349, 927–929 (2015).

    Article  CAS  Google Scholar 

  7. WHO Vector Control and Advisory Group. Fifth Meeting of the Vector Control and Advisory Group. (WHO-VCAG, Geneva, Switzerland, 2017). http://apps.who.int/iris/bitstream/10665/255824/1/WHO-HTM-NTD-VEM-2017.02-eng.pdf?ua=1

  8. American Society of Tropical Medicine and Hygiene. Vector Borne Zoonotic Dis. 3, 75–90 (2003).

  9. Benedict, M. et al. Vector Borne Zoonotic Dis. 8, 127–166 (2008).

    Article  CAS  Google Scholar 

  10. Brown, D.M., Alphey, L.S., McKemey, A., Beech, C. & James, A.A. Vector Borne Zoonotic Dis. 14, 291–299 (2014).

    Article  Google Scholar 

  11. Kolopack, P.A., Parsons, J.A. & Lavery, J.V. PLoS Negl. Trop. Dis. 9, e0003713 (2015).

    Article  Google Scholar 

  12. Lavery, J.V. et al. Trends Parasitol. 26, 279–283 (2010).

    Article  Google Scholar 

  13. Animal and Plant Health Inspection Service. Containment Guidelines for Nonindigenous, Phytophagous Arthropods and their Parasitoids and Predators (APHIS, Washington, DC, 2002). https://www.aphis.usda.gov/plant_health/permits/downloads/arthropod_biocontrol_containment_guidelines.pdf

  14. National Institutes of Health. NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (NIH, Bethesda, MD, 2016). https://osp.od.nih.gov/biotechnology/nih-guidelines/

  15. Animal and Plant Health Inspection Service. Permit User's Guide (APHIS, Washington, DC, 2012). https://www.aphis.usda.gov/biotechnology/downloads/permit_guidance.pdf

  16. Food and Drug Administration. Guidance for Industry #187 Regulation of Intentionally Altered Genomic DNA in Animals. (FDA, Rockville, MD, 2017). https://www.fda.gov/downloads/AnimalVeterinary/GuidanceComplianceEnforcement/GuidanceforIndustry/UCM113903.pdf

  17. World Health Organization-TDR and the Foundation for the National Institutes of Health. Guidance Framework for Testing of Genetically Modified Mosquitoes (WHO-TDR and FNIH, Geneva, Switzerland, 2014). http://www.who.int/tdr/publications/year/2014/guide-fmrk-gm-mosquit/en/

  18. North American Plant Protection Organization. Regional Standards for Phytosanitary Measures No. 27: Guidelines for Importation and Confined Field Release of Transgenic Arthropods in NAPPO Member Countries (NAPPO, Washington, DC, 2007). http://www.nappo.org/files/1814/3753/9399/RSPM27-e.pdf

  19. Convention on Biological Diversity. Guidance on Risk Assessment of Living Modified Organisms and Monitoring in the Context of Risk Assessment (CBD, Geneva, Switzerland, 2016). https://www.cbd.int/doc/meetings/bs/mop-08/official/bs-mop-08-08-add1-en.pdf

  20. EFSA Panel on Genetically Modified Organisms. EFSA J. 11, 3200 (2013).

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Correspondence to Robert M Friedman.

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E.B. and V.G. have filed for intellectual property that covers aspects of gene drives.

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Adelman, Z., Akbari, O., Bauer, J. et al. Rules of the road for insect gene drive research and testing. Nat Biotechnol 35, 716–718 (2017). https://doi.org/10.1038/nbt.3926

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