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  • Correspondence
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Rules of the road for insect gene drive research and testing

Nature Biotechnology volume 35, pages 716–718 (2017)Cite this article

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To the Editor:

Approximately two years ago, two of us (E.B. and V.G.) demonstrated the first experimental application of CRISPR–Cas9 to 'drive' a desired trait throughout a population of fruit flies1. In November 2015, this same team at the University of California, San Diego, joined with A.A.J. and others at the University of California, Irvine, to develop a CRISPR-based gene drive for population modification of the malaria vector mosquito Anopheles stephensi2. A month later, a group in the United Kingdom applied a CRISPR-based gene drive to another malaria vector, Anopheles gambiae3.

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References

  1. Gantz, V.M. & Bier, E. Science 348, 442–444 (2015).

    Article  CAS  Google Scholar 

  2. Gantz, V.M. et al. Proc. Natl. Acad. Sci. USA 112, E6736–E6743 (2015).

    Article  CAS  Google Scholar 

  3. Hammond, A. et al. Nat. Biotechnol. 34, 78–83 (2016).

    Article  CAS  Google Scholar 

  4. National Academies of Science, Engineering, and Medicine. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values (The National Academies Press, 2016).

  5. Carter, S.R. & Friedman, R.M. Policy and Regulatory Issues for Gene Drives in Insects: Workshop Report (J. Craig Venter Institute, San Diego, CA, 2016). http://www.jcvi.org/cms/fileadmin/site/research/projects/gene-drive-workshop/report-complete.pdf

    Google Scholar 

  6. Akbari, O.S. et al. Science 349, 927–929 (2015).

    Article  CAS  Google Scholar 

  7. WHO Vector Control and Advisory Group. Fifth Meeting of the Vector Control and Advisory Group. (WHO-VCAG, Geneva, Switzerland, 2017). http://apps.who.int/iris/bitstream/10665/255824/1/WHO-HTM-NTD-VEM-2017.02-eng.pdf?ua=1

  8. American Society of Tropical Medicine and Hygiene. Vector Borne Zoonotic Dis. 3, 75–90 (2003).

  9. Benedict, M. et al. Vector Borne Zoonotic Dis. 8, 127–166 (2008).

    Article  CAS  Google Scholar 

  10. Brown, D.M., Alphey, L.S., McKemey, A., Beech, C. & James, A.A. Vector Borne Zoonotic Dis. 14, 291–299 (2014).

    Article  Google Scholar 

  11. Kolopack, P.A., Parsons, J.A. & Lavery, J.V. PLoS Negl. Trop. Dis. 9, e0003713 (2015).

    Article  Google Scholar 

  12. Lavery, J.V. et al. Trends Parasitol. 26, 279–283 (2010).

    Article  Google Scholar 

  13. Animal and Plant Health Inspection Service. Containment Guidelines for Nonindigenous, Phytophagous Arthropods and their Parasitoids and Predators (APHIS, Washington, DC, 2002). https://www.aphis.usda.gov/plant_health/permits/downloads/arthropod_biocontrol_containment_guidelines.pdf

  14. National Institutes of Health. NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (NIH, Bethesda, MD, 2016). https://osp.od.nih.gov/biotechnology/nih-guidelines/

  15. Animal and Plant Health Inspection Service. Permit User's Guide (APHIS, Washington, DC, 2012). https://www.aphis.usda.gov/biotechnology/downloads/permit_guidance.pdf

  16. Food and Drug Administration. Guidance for Industry #187 Regulation of Intentionally Altered Genomic DNA in Animals. (FDA, Rockville, MD, 2017). https://www.fda.gov/downloads/AnimalVeterinary/GuidanceComplianceEnforcement/GuidanceforIndustry/UCM113903.pdf

  17. World Health Organization-TDR and the Foundation for the National Institutes of Health. Guidance Framework for Testing of Genetically Modified Mosquitoes (WHO-TDR and FNIH, Geneva, Switzerland, 2014). http://www.who.int/tdr/publications/year/2014/guide-fmrk-gm-mosquit/en/

  18. North American Plant Protection Organization. Regional Standards for Phytosanitary Measures No. 27: Guidelines for Importation and Confined Field Release of Transgenic Arthropods in NAPPO Member Countries (NAPPO, Washington, DC, 2007). http://www.nappo.org/files/1814/3753/9399/RSPM27-e.pdf

  19. Convention on Biological Diversity. Guidance on Risk Assessment of Living Modified Organisms and Monitoring in the Context of Risk Assessment (CBD, Geneva, Switzerland, 2016). https://www.cbd.int/doc/meetings/bs/mop-08/official/bs-mop-08-08-add1-en.pdf

  20. EFSA Panel on Genetically Modified Organisms. EFSA J. 11, 3200 (2013).

Download references

Acknowledgements

This Correspondence represents the views of the authors only, and not necessarily those of the entities with which they are affiliated.

Author information

Authors and Affiliations

  1. Texas A&M University, College Station, Texas, USA

    Zach Adelman

  2. University of California Riverside, Riverside, California, USA

    Omar Akbari & Mark Hoddle

  3. University of California San Diego, La Jolla, California, USA

    John Bauer, Ethan Bier, Cinnamon Bloss, Craig Callender, Peter Cowhey, Mary Devereaux, Valentino Gantz, Clark Gibson, Michael Kalichman, William McGinnis, Joseph M Vinetz & Brenda Wong

  4. Science Policy Consulting LLC, Arlington, Virginia, USA

    Sarah R Carter

  5. NIAID, National Institutes of Health, Bethesda, Maryland, USA

    Adriana Costero-Saint Denis

  6. US Food and Drug Administration, Rockville, Maryland, USA

    Brinda Dass & Larisa Rudenko

  7. North Carolina State University, Raleigh, North Carolina, USA

    Jason Delborne

  8. Legler Benbough Foundation, San Diego, California, USA

    Peter Ellsworth

  9. J. Craig Venter Institute, San Diego, California, USA

    Robert M Friedman

  10. California Institute of Technology, Pasadena, California, USA

    Bruce A Hay

  11. University of California Irvine, Irvine, California, USA

    Anthony A James

  12. Foundation for NIH, Rockville, Maryland, USA

    Stephanie James

  13. Office of Science Policy, National Institutes of Health, Bethesda, Maryland, USA

    Lyric Jorgenson

  14. University of California Berkeley, Berkeley, California, USA

    John Marshall

  15. Zagaya Foundation, Emeryville, California, USA

    Jack Newman

  16. US Department of Agriculture, Animal Plant Health Inspection Service, Washington, DC, USA

    Alan Pearson

  17. Donald Danforth Plant Science Center, St. Louis, Missouri, USA

    Hector Quemada

  18. Cornell University, Geneva, New York, USA

    Anthony Shelton

  19. Strategic Analysis, Inc., Arlington, Virginia, USA

    Jennifer Weisman

  20. US Environmental Protection Agency, Washington, DC, USA

    Chris Wozniak

Authors
  1. Zach Adelman
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  2. Omar Akbari
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  17. Bruce A Hay
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  18. Mark Hoddle
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  19. Anthony A James
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  20. Stephanie James
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  21. Lyric Jorgenson
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  22. Michael Kalichman
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  23. John Marshall
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  24. William McGinnis
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  25. Jack Newman
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  26. Alan Pearson
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  27. Hector Quemada
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  28. Larisa Rudenko
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  29. Anthony Shelton
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  30. Joseph M Vinetz
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  31. Jennifer Weisman
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  32. Brenda Wong
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  33. Chris Wozniak
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Corresponding author

Correspondence to Robert M Friedman.

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Competing interests

E.B. and V.G. have filed for intellectual property that covers aspects of gene drives.

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Adelman, Z., Akbari, O., Bauer, J. et al. Rules of the road for insect gene drive research and testing. Nat Biotechnol 35, 716–718 (2017). https://doi.org/10.1038/nbt.3926

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