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Making individualized drugs a reality

An Erratum to this article was published on 01 August 2017

This article has been updated

Magistral drug preparation offers a model to circumvent many of the technological, regulatory and financial challenges that prevent provision of the right drug at the right time to the right patient.

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Figure 1: Magistral production in a laminar flow at the Transvaal Pharmacy, a local pharmacy in The Hague, The Netherlands.

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  • 05 June 2017

    In the version of this article initially published, the line “Editor’s note: This article has been peer-reviewed.” was omitted. The error has been corrected in the HTML and PDF versions of the article.


  1. Olfson, M. & Marcus, S.C. Health Aff. (Millwood) 32, 1116–1125 (2013).

    Article  Google Scholar 

  2. Le Tourneau, C. et al. Lancet Oncol. 16, 1324–1334 (2015).

    Article  CAS  Google Scholar 

  3. Pirmohamed, M. et al. Br. Med. J. 329, 15–19 (2004).

    Article  Google Scholar 

  4. Jameson, J. & Longo, D.L. N. Engl. J. Med. 372, 2229–2234 (2015).

    Article  CAS  Google Scholar 

  5. Faulkner, E. et al. Value Health 15, 1162–1171 (2012).

    Article  Google Scholar 

  6. Carrera, P.M. & Ormond, M. Maturitas 82, 94–99 (2015).

    Article  Google Scholar 

  7. Cohen, J.P. Nat. Biotechnol. 29, 751–756 (2012).

    CAS  Google Scholar 

  8. de Bono, J.S. & Ashworth, A. Nature 467, 543–549 (2010).

    Article  CAS  Google Scholar 

  9. Damkier, P. Int. J. Clin. Pharm. 37, 669–670 (2015).

    Article  Google Scholar 

  10. Collins, F.S. & Varmus, H. N. Engl. J. Med. 372, 793–795 (2015).

    Article  CAS  Google Scholar 

  11. Okie, S. N. Engl. J. Med. 361, 737–740 (2009).

    Article  CAS  Google Scholar 

  12. Avorn, J. N. Engl. J. Med. 367, 193–197 (2012).

    Article  CAS  Google Scholar 

  13. Frueh, F.W. Value Health 16 Suppl, S27–S31 (2013).

    Article  Google Scholar 

  14. Fleck, L.M. Urol. Oncol. 32, 202–206 (2014).

    Article  Google Scholar 

  15. Kalia, M. Metabolism 62 Suppl 1, S1–14 (2013).

    Google Scholar 

  16. Moors, E.H., Cohen, A.F. & Schellekens, H. Drug Discov. Today 19, 1711–1720 (2014).

    Article  Google Scholar 

  17. European Public Assessment Report Glybera (EMA Website)

  18. Aronson, N. Ann. NY Acad. Sci. 1346, 81–89 (2015).

    Article  Google Scholar 

  19. Abernethy, A. et al. Clin. Cancer Res. 20, 1081–1086 (2014).

    Article  Google Scholar 

  20. Steger, K. et al. J. Biomol. Screen. 20, 545–551 (2015).

    Article  CAS  Google Scholar 

  21. Ge, X. et al. J. Am. Chem. Soc. 127, 11228–11229 (2005).

    Article  CAS  Google Scholar 

  22. Topol, E.J. N. Engl. J. Med. 351, 1707–1709 (2004).

    Article  CAS  Google Scholar 

  23. Minghetti, P., Pantano, D., Gennari, C.G. & Casiraghi, A. Health Policy 117, 328–333 (2014).

    Article  Google Scholar 

  24. Qureshi, N., Wesolowicz, L., Stievater, T. & Lin, A.T. J. Manag. Care Spec. Pharm. 20, 1183–1191 (2014).

    PubMed  Google Scholar 

  25. McKoy, J.M. et al. Transfusion 48, 1754–1762 (2008).

    Article  Google Scholar 

  26. Kooijman, M., van Meer, P.J., Moors, E.H. & Schellekens, H. Expert Opin. Drug Saf. 11, 797–801 (2012).

    Article  Google Scholar 

  27. van Meer, P.J. et al. MAbs 5, 810–816 (2013).

    Article  Google Scholar 

  28. Schneider, C.K. & Kalinke, U. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50, 1213–1220 (2007).

    Article  CAS  Google Scholar 

  29. Patten, P.A. & Schellekens, H. Dev. Biol. 112, 81–97 (2003).

    CAS  Google Scholar 

  30. Bach, P.B., Conti, R.M., Muller, R.J., Schnorr, G.C. & Saltz, L.B. Br. Med. J. 352, i788 (2016).

    Article  Google Scholar 

  31. Ciriminna, R. et al. Nanoscale 6, 6293–6300 (2014).

    Article  CAS  Google Scholar 

  32. Gising, J., Odell, L.R. & Larhed, M. Org. Biomol. Chem. 10, 2713–2729 (2012).

    Article  CAS  Google Scholar 

  33. Szymkuć, S. et al. Angew. Chem. Int. Edn Engl. 55, 5904–5937 (2016).

    Article  Google Scholar 

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Correspondence to Huub Schellekens.

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Schellekens, H., Aldosari, M., Talsma, H. et al. Making individualized drugs a reality. Nat Biotechnol 35, 507–513 (2017).

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