Supplementary Figure 3: GR metrics and entropies for the CTRP dataset. | Nature Biotechnology

Supplementary Figure 3: GR metrics and entropies for the CTRP dataset.

From: Alternative drug sensitivity metrics improve preclinical cancer pharmacogenomics

Supplementary Figure 3

(a) Entropies for GR50 and GR2μM for each drug in the CTRP dataset. Size of the circle reflects the mutual information between GR50 and GR2μM. (b) Joint entropy of GR50 and GR2μM (H50+2μM) metrics plotted against the entropy of the GRAOC value (HAOC). (c) Distribution of entropies for GR50 (H50), GR2μM (H2μM), GRAOC (HAOC), and joint entropy of GR50 and GR2μM (H50+2μM). Red line marks the median value. (d) Each panel shows GR2μM plotted against GR50 values across all cell lines for drugs or drug combinations with the highest joint entropy of GR50 and GR2μM (H50+2μM). For illustration purposes GR50 values are capped at 31 μM.

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