Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Reprogramming the diseased brain

Direct conversion of astrocytes to dopamine neurons in vivo offers fresh optimism for the development of improved Parkinson's disease therapies.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Alternative strategies for regenerative medicine in Parkinson's disease.


  1. Rivetti di Val Cervo, P. et al. Nat. Biotechnol. 35, 444–452 (2017).

    Article  Google Scholar 

  2. Lindvall, O. et al. Science 247, 574–577 (1990).

    Article  CAS  Google Scholar 

  3. Grealish, S. et al. Cell Stem Cell 15, 653–665 (2014).

    Article  CAS  Google Scholar 

  4. Doi, D. et al. Stem Cell Rep. 2, 337–350 (2014).

    Article  CAS  Google Scholar 

  5. La Manno, G. et al. Cell 167, 566–580.e19 (2016).

    Article  CAS  Google Scholar 

  6. Caiazzo, M. et al. Nature 476, 224–227 (2011).

    Article  CAS  Google Scholar 

  7. Liu, X. et al. Cell Res. 22, 321–332 (2012).

    Article  CAS  Google Scholar 

  8. Masserdotti, G., Gascón, S. & Götz, M. Development 143, 2494–2510 (2016).

    Article  CAS  Google Scholar 

  9. Cederfjäll, E. et al. Sci. Rep. 3, 2157 (2013).

    Article  Google Scholar 

  10. Richardson, R.M. et al. Mol. Ther. 19, 1048–1057 (2011).

    Article  CAS  Google Scholar 

  11. Marks, W.J. Jr., Baumann, T.L. & Bartus, R.T. Hum. Gene Ther. 27, 522–527 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Stephen B Dunnett or Anne E Rosser.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dunnett, S., Rosser, A. Reprogramming the diseased brain. Nat Biotechnol 35, 426–428 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research