Our annual survey highlights several academic startups developing immunotherapies as well as ventures focusing on microbiomes, proteostasis, integrin biology, nucleic acid delivery and subcellular imaging.
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Change history
25 May 2017
In the version of this article initially published, on p.326, column 3, Shawn Marcell was described as “an economist turned pathologist,” rather than “an economist and entrepreneur.” Four lines below, his name was misspelled as “Marcel.” On p.329, the thumbnail caption named Kuball CEO; he is CSO, as it says in the text. On p.330, column 3, David Pompliano was incorrectly said to be “a partner at Apple Tree Partners (New York).” On p.331, column 1, Exicure CEO Giljohann’s first name was given as John in the caption; it is David. In column 2, paragraph 1 (and also in column 3, paragraph 3), AuraSense should have been AuraSense Therapeutics; paragraph 2, line 1, “AuraSense described” should have been “the Mirkin group described”; paragraph 4, line 1, “Exicure has published” should have been “The Mirkin group has published”; last paragraph, “upfront payment and equity investment” should have been “upfront payment and potential equity investment.” In column 3, paragraph 1, “ectopic dermatitis” should have been “atopic dermatitis”; in paragraph 2, the last half of the last sentence, “to enter a phase 1 trial in combination with a checkpoint inhibitor to treat solid tumors in the first half of 2017” should have read “to enter a phase 1 safety study in healthy volunteers in the first half of 2017, and is expected to enter a trial in combination with a checkpoint inhibitor to treat solid tumors in the first half of 2018.” The errors have been corrected in the HTML and PDF versions of the article.
References
Oldenborg, P.-A. et al. Role of CD47 as a marker of self on red blood cells. Science 288, 2051–2054 (2000).
Jaiswal, S. et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 138, 271–285 (2009).
Majeti, R. et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 138, 286–299 (2009).
Chao, M.P. et al. Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci. Transl. Med. 2, 63ra94 (2010).
Horrigan, S.K. Replication study: the CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. eLife 6, e18173 (2017).
Willingham, S.B. et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc. Natl. Acad. Sci. USA 109, 6662–6667 (2012).
Kojima, Y. et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature 536, 86–90 (2016).
Palchaudhuri, R. et al. Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nat. Biotechnol. 34, 738–745 (2016).
Hsiao, E.Y. et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155, 1451–1463 (2013).
Sampson, T.R. et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease. Cell 167, 1469–1480.e12 (2016).
Lee, J.H. et al. Highly multiplexed subcellular RNA sequencing in situ. Science 343, 1360–1363 (2014).
Munger, J.S. et al. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96, 319–328 (1999).
Horan, G.S. et al. Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am. J. Respir. Crit. Care Med. 177, 56–65 (2008).
Krönke, J. et al. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science 343, 301–305 (2014).
Krönke, J. et al. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science 343, 301–305 (2014).
Winter, G.E. et al. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 348, 1376–1381 (2015).
Dai, H., Wang, Y., Lu, X. & Han, W. Chimeric antigen receptors modified T-cells for cancer therapy. J. Natl. Cancer Inst. 108, djv439 (2016).
Bonneville, M., O'Brien, R.L. & Born, W.K. Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat. Rev. Immunol. 10, 467–478 (2010).
Gentles, A.J. et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat. Med. 21, 938–945 (2015).
Fournié, J.J. et al. What lessons can be learned from gδ T cell-based cancer immunotherapy trials? Cell. Mol. Immunol. 10, 35–41 (2013).
Marcu-Malina, V. et al. Redirecting αβ T cells against cancer cells by transfer of a broadly tumor-reactive gdT-cell receptor. Blood 118, 50–59 (2011).
Sebestyen, Z. et al. RhoB mediates phosphoantigen recognition by Vγ9Vδ2T cell receptor. Cell Rep. 15, 1973–1985 (2016).
Choi, C.H., Hao, L., Narayan, S.P., Auyeung, E. & Mirkin, C.A. Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates. Proc. Natl. Acad. Sci. USA 110, 7625–7630 (2013).
Radovic-Moreno, A.F. et al. Immunomodulatory spherical nucleic acids. Proc. Natl. Acad. Sci. USA 112, 3892–3897 (2015).
Wang, J. & Quake, S.R. RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection. Proc. Natl. Acad. Sci. USA 111, 13157–13162 (2014).
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Bouchie, A., DeFrancesco, L., Sheridan, C. et al. Nature Biotechnology's academic spinouts of 2016. Nat Biotechnol 35, 322–333 (2017). https://doi.org/10.1038/nbt.3847
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DOI: https://doi.org/10.1038/nbt.3847
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