Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Fleeting factors, turning back time

Nature Biotechnology volume 35, pages 218–220 (2017)Cite this article

Subjects

Old cells and tissues become young again after a short dose of reprogramming factors.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Effects of the expression of reprogramming factors on tissue and organismal aging.

References

  1. Ocampo, A. et al. Cell 167, 1719–1733 (2016).

    Article  CAS  Google Scholar 

  2. Mercken, E.M., Carboneau, B.A., Krzysik-Walker, S.M. & de Cabo, R. Ageing Res. Rev. 11, 390–398 (2012).

    Article  Google Scholar 

  3. Conboy, I.M. et al. Nature 433, 760–764 (2005).

    Article  CAS  Google Scholar 

  4. Villeda, S.A. et al. Nat. Med. 20, 659–663 (2014).

    Article  CAS  Google Scholar 

  5. Baker, D.J. et al. Nature 479, 232–236 (2011).

    Article  CAS  Google Scholar 

  6. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  7. Mahmoudi, S. & Brunet, A. Curr. Opin. Cell Biol. 24, 744–756 (2012).

    Article  CAS  Google Scholar 

  8. Rando, T.A. & Chang, H.Y. Cell 148, 46–57 (2012).

    Article  CAS  Google Scholar 

  9. Abad, M. et al. Nature 502, 340–345 (2013).

    Article  CAS  Google Scholar 

  10. Hou, P. et al. Science 341, 651–654 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Thomas A. Rando is at the Glenn Center for the Biology of Aging at Stanford University, Stanford, California, USA.,

    Thomas A Rando

Authors
  1. Thomas A Rando
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas A Rando.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rando, T. Fleeting factors, turning back time. Nat Biotechnol 35, 218–220 (2017). https://doi.org/10.1038/nbt.3817

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.3817

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing