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Hearing in the mouse of Usher

Hearing and balance are rescued by a synthetic virus that delivers a transgene to the inner ear of neonatal mice.

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Figure 1: Structure, function, and viral transduction of the inner ear.


  1. Olusanya, B.O., Neumann, K.J. & Saunders, J.E. Bull. World Health Organ. 92, 367–373 (2014).

    Article  Google Scholar 

  2. Van Camp, G. & Smith, R.J.H. Accessed: January 28, 2017.

  3. Landegger, L.D. et al. Nat. Biotechnol. 35, 280–284 (2017).

    Article  CAS  Google Scholar 

  4. Pan, B. et al. Nat. Biotechnol. 35, 264–272 (2017).

    Article  CAS  Google Scholar 

  5. Ren, T., He, W. & Kemp, D. Proc. Natl. Acad. Sci. USA 113, 9910–9915 (2016).

    Article  CAS  Google Scholar 

  6. Akil, O. et al. Neuron 75, 283–293 (2012).

    Article  CAS  Google Scholar 

  7. Askew, C. et al. Sci. Transl. Med. 7, 295ra108 (2015).

    Article  Google Scholar 

  8. Zinn, E. et al. Cell Rep. 12, 1056–1068 (2015).

    Article  CAS  Google Scholar 

  9. Mathur, P. & Yang, J. Biochim. Biophys. Acta 1852, 406–420 (2015).

    Article  CAS  Google Scholar 

  10. Lentz, J.J. et al. Nat. Med. 19, 345–350 (2013).

    Article  CAS  Google Scholar 

  11. Lentz, J.J. et al. Dev. Neurobiol. 70, 253–267 (2010).

    Article  CAS  Google Scholar 

  12. Hepper, P.G. & Shahidullah, B.S. Arch. Dis. Child. 71, F81–F87 (1994).

    Article  CAS  Google Scholar 

  13. Depreux, F.F. et al. Nucleic Acids Res. 44, 9519–9529 (2016).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Trapani, I. et al. Hum. Mol. Genet. 24, 6811–6825 (2015).

    Article  CAS  Google Scholar 

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Karen Thiebes, Ph.D., created the artwork for Figure 1. Work in the author's laboratory is funded by the Hearing Health Foundation's Hearing Restoration Project and by the National Institute on Deafness and Other Communication Disorders (NIDCD).

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Correspondence to John V Brigande.

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The author declares no competing financial interests.

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Brigande, J. Hearing in the mouse of Usher. Nat Biotechnol 35, 216–218 (2017).

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