Worth the RISC?

The long, tortuous race to market a therapeutic based on RNA interference (RNAi) may be nearing its end. Ken Garber reports.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: siRNA therapies face many barriers to reaching their targets.

References

  1. 1

    Garber, K. Nat. Biotechnol. 34, 1213–1214 (2016)

    CAS  Article  Google Scholar 

  2. 2

    Elbashir, S.M. et al. Nature 411, 494–498 (2001).

    CAS  Article  Google Scholar 

  3. 3

    Zuckerman, J.E. et al. Proc. Natl. Acad. Sci. USA 111, 11449–11454 (2014).

    CAS  Article  Google Scholar 

  4. 4

    Tabernero, J. et al. Cancer Discov. 3, 406–417 (2013).

    CAS  Article  Google Scholar 

  5. 5

    Coelho, T. et al. N. Engl. J. Med. 369, 819–829 (2013).

    CAS  Article  Google Scholar 

  6. 6

    Nair, J.K. et al. J. Am. Chem. Soc. 136, 16958–16961 (2014).

    CAS  Article  Google Scholar 

  7. 7

    Fitzgerald, K. et al. N. Engl. J. Med. 376, 41–51 (2017).

    CAS  Article  Google Scholar 

  8. 8

    Grimm, D. et al. Nature 441, 537–541 (2006).

    CAS  Article  Google Scholar 

  9. 9

    Shen, W., Liang, X.H., Sun, H. & Crooke, S.T. Nucleic Acids Res. 43, 4569–4578 (2015).

    CAS  Article  Google Scholar 

  10. 10

    Janas, M.M. et al. Nucleic Acids Ther. doi:1089/nat.2016.0639 (2016).

  11. 11

    Pasi K.J. et al. Blood 128, 1397 (2016).

    Google Scholar 

  12. 12

    Ragni, M.V. Blood 128, 2572 (2016).

    Google Scholar 

  13. 13

    Sardh, E. et al. Blood 128, 2318 (2016).

    Google Scholar 

  14. 14

    Meade, B.R. et al. Nat. Biotechnol. 32, 1256–1261 (2014).

    CAS  Article  Google Scholar 

  15. 15

    Bartlett, D.W., Su, H., Hildebrandt, I.J., Weber, W.A. & Davis, M.E. Proc. Natl. Acad. Sci. USA 104, 15549–15554 (2007).

    CAS  Article  Google Scholar 

  16. 16

    Semple, S.C. et al. Nat. Biotechnol. 28, 172–176 (2010).

    CAS  Article  Google Scholar 

  17. 17

    Judge, A. & MacLachlan, I. Hum. Gene Ther. 19, 111–124 (2008).

    CAS  Article  Google Scholar 

  18. 18

    Barros, S.A. & Gollob, J.A. Adv. Drug Deliv. Rev. 64, 1730–1737 (2012).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Garber, K. Worth the RISC?. Nat Biotechnol 35, 198–202 (2017). https://doi.org/10.1038/nbt.3810

Download citation

Further reading