Supplementary Figure 1 : Analysis of hair bundle morphology in Ush1c c.216G>A mice at P18 by SEM.

From: Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c

Supplementary Figure 1

(a-c) Heterozygous c.216GA mice displayed normal hair bundle morphology at P18. (d-i) Disorganized hair bundles were observed along the organ of P18 Homozygous c.216AA mice. (j-l) IHCs hair bundle were mildly disrupted (arrows) in c.216AA mice. Distance measured from apex tip: Base 3.5-4 mm; Mid 1.8-2.2 mm; Apex 0.6-0.8 mm. Scale bar a-f; j-l: 5 μm; g-i: 1 μm.