Exploring protein sequence–function landscapes

The effects of sequence variation on function are elucidated by a study of protein evolution.

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Figure 1: Origins of covariation in a multiple sequence alignment.

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Acknowledgements

Supported by NIH R01GM104397 (J.W.T.), NIH training grant T32-GM007183 (T.N.S.), and a Graduate Research Fellowship from the National Science Foundation (T.N.S.).

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Correspondence to Joseph W Thornton.

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The authors declare no competing financial interests.

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Starr, T., Thornton, J. Exploring protein sequence–function landscapes. Nat Biotechnol 35, 125–126 (2017). https://doi.org/10.1038/nbt.3786

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