Research Highlights

    Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

    T-cell transfer therapy targeting mutant KRAS in cancer

    Tran, E. et al. N. Engl. J. Med. 375, 2255–2262 (2016)

    Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

    Dewey, F.E. et al. Science 354, aaf6814 (2016)

    Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens

    Dixit, A. et al. Cell 167, 1853–1866.e17 (2016)

    A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response

    Adamson, B. et al. Cell 167, 1867–1882.e21 (2016)

    Dissecting immune circuits by linking CRISPR-pooled screens with single-cell RNA-seq

    Jaitin, D.A. et al. Cell 167, 1883–1896.e15 (2016)

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    Research Highlights. Nat Biotechnol 35, 127 (2017). https://doi.org/10.1038/nbt.3785

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