Supplementary Figure 2: Evolutionary statistical energy landscapes capture mutational sensitivity of sites | Nature Biotechnology

Supplementary Figure 2: Evolutionary statistical energy landscapes capture mutational sensitivity of sites

From: Mutation effects predicted from sequence co-variation

Supplementary Figure 2

Computed mutational sensitivities per position (average difference in evolutionary statistical energy ΔE across all possible substitutions for each site) based on the epistatic model agree with experimental mutational sensitivities on 20 analyzed single-substitution landscapes for 15 biomolecules as measured by Spearman's rank correlation coefficient ρ. For correlations with the effects of individual substitutions, see Fig. 3a.

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