Supplementary Figure 7: Epistatic interactions critical for accurate prediction of functional residues | Nature Biotechnology

Supplementary Figure 7: Epistatic interactions critical for accurate prediction of functional residues

From: Mutation effects predicted from sequence co-variation

Supplementary Figure 7

Across the proteins with high-throughput datasets where epistatic interactions lead to better agreement with the experimental data (first column), certain subgroups of substitutions contribute to the overall reduction in error, while others are predicted with comparable or slightly better accuracy by the independent model (for definitions of subgroups, see Online Methods).

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