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A community-based model of rapid autopsy in end-stage cancer patients

Nature Biotechnology volume 34, pages 10101014 (2016) | Download Citation

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Acknowledgements

The CASCADE program was funded initially by a grant from the Peter MacCallum Cancer Foundation. The CASCADE investigators would like to acknowledge the support and guidance of the CASCADE Management Committee. kConFab wishes to thank E. Niedermayr, all the kConFab research nurses and staff, the heads and staff of Family Cancer Clinics and the Clinical Follow Up Study (which has received funding from the NHMRC, the National Breast Cancer Foundation, Cancer Australia and the US National Institutes of Health) for contributions to this resource, and the many families who contribute to kConFab. We sincerely thank the hospital and hospice staff involved in the care of CASCADE participants, the staff at Tobin Brothers Funerals, the Victorian Institute of Forensic Medicine and the participants and their family members. This work was supported by the Peter MacCallum Cancer Foundation; the National Health and Medical Research Council (APP631701 and APP1092856 to D.B., APP1035721 to M.G.L; APP1002648 to G.P.R., APP1035298 to C.F., APP628735 to M.S., APP1054618 to A.P, and APP1062702 to C.S.) to Ovarian Cancer Australia to D.B., the Victorian Cancer Agency (EOI09_27 and CRF13026 (clinical research fellowship to L.M.)); the National Breast Cancer Foundation of Australia (14-067, Infrastructure Grant (kConFab)); the Cancer of the Prostate Translational Research in Victoria (CAPTIV) Collaboration; Amgen (S.S.); the Peter and Lyndy White Foundation; the ANZ Trustees; the Queensland Cancer Fund; the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia; the Cancer Foundation of Western Australia; Prostate Cancer Foundation of Australia (Movember Young Investigator grant to M.G.L.); Pfizer Australia; the Victorian Endowment for Science, Knowledge and Innovation (M.S.); the Lorenzo and Pamela Galli Charitable Trust; the Cancer Council Victoria Sir Edward Dunlop Fellowship in Cancer Research (CS); CRC for Cancer Therapeutics (M.T.) and the Stafford Fox Medical Research Foundation. Work performed by C.S. was made possible through Victorian State Government Operational Infrastructure Support, Australian Government NHMRC IRIISS and the Australian Cancer Research Foundation.

Author information

Affiliations

  1. Cancer Genomics Program, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Kathryn Alsop
    • , Heather Thorne
    • , Elizabeth Christie
    •  & David D Bowtell
  2. kConFab, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Heather Thorne
  3. Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Shahneen Sandhu
    • , Anne Hamilton
    • , Linda Mileshkin
    • , Sumitra Ananda
    • , Sherene Loi
    • , Peter Savas
    • , Grant McArthur
    • , Benjamin Solomon
    • , Prudence A Francis
    • , Sarah-Jane Dawson
    •  & Mark Shackleton
  4. Department of Oncology, the Royal Women's Hospital, Parkville, Victoria, Australia.

    • Anne Hamilton
    • , Orla McNally
    • , Sumitra Ananda
    •  & Julene Hallo
  5. Department of Medicine, Dentistry and Health Sciences, the University of Melbourne, Parkville, Victoria, Australia.

    • Anne Hamilton
    •  & Odette Spruyt
  6. Cancer Development and Treatment Laboratory, Research Department, Peter MacCallum Cancer, Melbourne, Victoria, Australia.

    • Christopher Mintoff
    • , Samantha Boyle
    • , Clare Fedele
    •  & Mark Shackleton
  7. Sir Peter MacCallum Department of Oncology, the University of Melbourne, Victoria, Australia.

    • Elizabeth Christie
    • , Linda Mileshkin
    • , Sherene Loi
    • , Lisa Devereux
    • , Clare Fedele
    • , Zhi Ling Teo
    • , Nicole M Haynes
    • , Ricky W Johnstone
    • , Anthony T Papenfuss
    • , Grant McArthur
    • , Benjamin Solomon
    • , Gillian Mitchell
    • , Sarah-Jane Dawson
    • , Mark Shackleton
    •  & David D Bowtell
  8. Department of Pain and Palliative Care, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Odette Spruyt
  9. Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Scott Williams
  10. Department of Obstetrics and Gynaecology, the University of Melbourne, Parkville, Victoria, Australia.

    • Orla McNally
  11. Translational Breast Cancer Genomics and Therapeutics Laboratory, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Sherene Loi
    • , Peter Savas
    •  & Zhi Ling Teo
  12. The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

    • Clare Scott
    • , Monique Topp
    • , Gwo Ho
    •  & Ismael A Vergara
  13. The Victorian Institute of Forensic Medicine, Southbank, Victoria, Australia.

    • Patricia O'Brien
    • , Sameera Gunawardena
    • , Clare Hampson
    • , Kate Strachan
    • , Rufaro Diana Jaravaza
    • , Victoria Francis
    • , Gregory Young
    • , David Ranson
    • , Ravindra Samaranayake
    • , Mohammed Madadin
    • , Jodie Leditschke
    •  & Stephen Cordner
  14. Tobin Brothers Funerals, Victoria, Australia.

    • David Stevens
  15. Department of Pathology, the University of Melbourne, Parkville, Victoria, Australia.

    • Clare Fedele
    •  & Paul Waring
  16. Department of Physiology, Biomedicine Discovery Institute, Monash Partners Comprehensive Cancer Consortium, Monash University, Clayton, Victoria, Australia.

    • Renea A Taylor
  17. Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash Partners Comprehensive Cancer Consortium, Monash University, Clayton, Victoria, Australia.

    • Melissa M Papargiris
    • , Mitchell G Lawrence
    • , Hong Wang
    •  & Gail P Risbridger
  18. Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Nicole M Haynes
    • , Mikolaj Medon
    • , Ricky W Johnstone
    • , Eva Vidacs
    •  & Anthony T Papenfuss
  19. Division of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Mikolaj Medon
    •  & David Gyorki
  20. Molecular Genomics, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Gisela Mir Arnau
  21. Bioinformatics and Cancer Genomics, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Ismael A Vergara
    •  & Anthony T Papenfuss
  22. The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Shirley Carvosso
  23. Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Christopher Angel
  24. The Department of Surgery, the University of Melbourne, Parkville, Victoria, Australia.

    • David Gyorki
  25. The Jack Brockhoff Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Gillian Mitchell
    •  & Sue Shanley
  26. Hereditary Cancer Program, BC Cancer Agency, Vancouver, Canada.

    • Gillian Mitchell
  27. Molecular Biomarkers and Translational Genomics Laboratory, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Sarah-Jane Dawson
  28. Department of Nursing, the Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

    • Amy Haffenden
    •  & Erin Tidball
  29. Department of Pathology, the Royal Women's Hospital, Parkville, Victoria, Australia.

    • Mila Volchek
    •  & Jan Pyman
  30. Department of Pathology, University of Dammam, Dammam, Saudi Arabia.

    • Mohammed Madadin
  31. Department of Forensic Medicine, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia.

    • Jodie Leditschke
    •  & Stephen Cordner
  32. Centre for Cancer Research, Westmead Millennium Institute, the University of Sydney and Departments of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.

  33. QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

  34. The Garvan Institute, Sydney, New South Wales, Australia.

    • David D Bowtell

Consortia

  1. the Melbourne Melanoma Project

    1. Division of Cancer Medicine, Peter MacCallum Cancer Centre
    2. Sir Peter MacCallum Department of Oncology, the University of Melbourne
  2. the Australian Ovarian Cancer Study Group (AOCS)

    1. Cancer Genomics Program, Research Department, Peter MacCallum Cancer Centre
    2. Centre for Cancer Research, Westmead Millennium Institute, the University of Sydney and Departments of Gynaecological Oncology, Westmead Hospital
    3. QIMR Berghofer Medical Research Institute
  3. the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab)

    1. kConFab, Research Department, Peter MacCallum Cancer Centre

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to David D Bowtell.

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    Supplementary Methods, Supplementary Figures 1–3, and Supplementary Table 1

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DOI

https://doi.org/10.1038/nbt.3674

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