Correspondence | Published:

The impact of personal genomics on risk perceptions and medical decision-making

Nature Biotechnology volume 34, pages 912918 (2016) | Download Citation

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & J. Am. Med. Assoc. 300, 2669–2671 (2008).

  2. 2.

    , & N. Engl. J. Med. 364, 524–534 (2011).

  3. 3.

    , & Genet. Epidemiol. 36, 66–70 (2012).

  4. 4.

    , , & Genet. Med. 13, 409–414 (2011).

  5. 5.

    et al. N. Engl. J. Med. 361, 245–254 (2009).

  6. 6.

    , , & J. Genet. Couns. 21, 413–422 (2012).

  7. 7.

    et al. Public Health Genomics 18, 216–224 (2015).

  8. 8.

    & Curr. Genet. Med. Rep. 1, 182–200 (2013).

  9. 9.

    et al. Clin. Genet. 87, 117–123 (2015).

  10. 10.

    , , & Genet. Test. Mol. Biomarkers 16, 1165–1171 (2012).

  11. 11.

    , & Am. Econ. Rev. 103, 804–830 (2013).

  12. 12.

    , , & J. Public Econ. 94, 1041–1050 (2010).

  13. 13.

    & Am. Econ. J. Microecon. 3, 114–138 (2011).

  14. 14.

    et al. Proc. Natl. Acad. Sci. USA 110, 16396–16401 (2013).

  15. 15.

    et al. Proc. Natl. Acad. Sci. USA 109, 17058–17062 (2012).

  16. 16.

    , & Nat. Neurosci. 14, 1475–1479 (2011).

  17. 17.

    & Science 185, 1124–1131 (1974).

  18. 18.

    J. Finance 70, 2029–2062 (2015).

  19. 19.

    Q. J. Econ. 75, 643–669 (1961).

  20. 20.

    J. Health Econ. 22, 1073–1084 (2003).

Download references

Acknowledgements

We thank Tali Sharot, Alec Brandon, Jean Tirole, Alexandra Rodman, Daniel Fehder, Abhishek Nagaraj, Rebecca Grunberg, Roberto Fernandez, Sarah Kalia and members of the PGen Study Group (particularly Kurt Christensen, Deanna Alexis Carere, and Joanna L. Mountain). Members of the PGen Study Group are listed in Supplementary Note 2. The PGen Study is supported by the US National Institutes of Health (NIH) National Human Genome Research Institute (R01-HG005092). R.C.G. was additionally supported by the following NIH grants: U01-HG006500, U19-HD077671, U01-HG008685 and U41-HG006834.

Author information

Affiliations

  1. Sloan School of Management, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

    • Joshua L Krieger
    •  & Fiona Murray
  2. Department of Health Behavior & Health Education, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.

    • J Scott Roberts
  3. Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Partners HealthCare Personalized Medicine, the Broad Institute and Harvard Medical School, Boston, Massachusetts, USA.

    • Robert C Green

Authors

  1. Search for Joshua L Krieger in:

  2. Search for Fiona Murray in:

  3. Search for J Scott Roberts in:

  4. Search for Robert C Green in:

Contributions

J.L.K. formulated the research question, designed and performed the analyses, prepared the figures and wrote the manuscript. F.M. helped with the research design, analyses, and manuscript writing. R.C.G. and J.S.R. designed and implemented the surveys, in their roles as the primary investigators of the Impact of Personal Genomics (PGen) study, and advised on the preparation of the figures and the manuscript. All authors edited and approved the manuscript.

Competing interests

R.C.G. receives personal compensation for speaking or consulting from AIA, Helix, Illumina, Invitae, Prudential and Roche.

Corresponding author

Correspondence to Joshua L Krieger.

Supplementary information

PDF files

  1. 1.

    Supplementary Text and Figures

    Supplementary Methods, Supplementary Notes 1 and 2, Supplementary Figures 1–5 and Supplementary Tables 1–9

Excel files

  1. 1.

    Supplementary Data

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nbt.3661

Editor's note: This article has been peer-reviewed.

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing