A genome smaller than any known natural or reduced genome has been designed, synthesized and shown capable of sustaining self-replication in a free-living environment.
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Vickers, C. The minimal genome comes of age. Nat Biotechnol 34, 623–624 (2016). https://doi.org/10.1038/nbt.3593
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DOI: https://doi.org/10.1038/nbt.3593
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