Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

Enhancer–promoter interactions are encoded by complex genomic signatures on looping chromatin

Whalen, S., Truty R.M. & Pollard, K.S. Nat. Genet. doi:10.1038/ng.3539 (2016)

Restoring cortical control of functional movement in a human with quadriplegia

Bouton, C.E. et al. Nature doi:10.1038/nature17435 (2016)

Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis

Xiao, Y., Bowen, C.H., Liu, D. & Zhang, F. Nat. Chem. Bio. doi:10.1038/nchembio.2046 (2016)

A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy

Lee, H. et al. Nat. Nanotechnol. doi:10.1038/nnano.2016.38 (2016)

The public repository of xenografts enables discovery and randomized phase II-like trials in mice

Townsend, E. et al. Cancer Cell 29, 574–586 (2016)