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Receptor combinations hone T-cell therapy

The safety of engineered T cells is improved through gated expression of two chimeric antigen receptors.

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Figure 1: Cancer-cell-specific T-cell activation by dual-tumor antigen targeting to reduce toxicity.


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Correspondence to Thomas Blankenstein.

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Blankenstein, T. Receptor combinations hone T-cell therapy. Nat Biotechnol 34, 389–391 (2016).

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