Digital medicine offers the possibility of continuous monitoring, behavior modification and personalized interventions at low cost, potentially easing the burden of chronic disease in cost-constrained healthcare systems.
Subscribe to Journal
Get full journal access for 1 year
only $20.83 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Centers for Disease Control and Prevention, National Center for Health Statistics. Leading causes of death, 1900–1998. http://www.cdc.gov/nchs/data/dvs/lead1900_98.pdf (Accessed November 28, 2015).
Centers for Disease Control and Prevention. Chronic disease overview. http://www.cdc.gov/chronicdisease/overview/ (Accessed November 28, 2015).
Elenko, E., Underwood, L. & Zohar, D. Nat. Biotechnol. 33, 456–461 (2015).
Ward, B.W., Schiller, J.S. & Goodman, R.A. Prev. Chronic Dis. 11, E62 (2014).
Centers for Disease Control and Prevention. Deaths and mortality. http://www.cdc.gov/nchs/fastats/deaths.htm (Accessed November 24, 2015).
Crimmins, E.M. Gerontologist 55, 901–911 (2015).
Gerteis, J. et al. Multiple Chronic Conditions Chartbook. http://www.ahrq.gov/sites/default/files/wysiwyg/professionals/prevention-chronic-care/decision/mcc/mccchartbook.pdf (Agency for Healthcare Research and Quality, April 2014).
US Department of Health & Human Services. Better, smarter, healthier. http://www.hhs.gov/about/news/2015/01/26/better-smarter-healthier-in-historic-announcement-hhs-sets-clear-goals-and-timeline-for-shifting-medicare-reimbursements-from-volume-to-value.html (26 January 2015).
Delbanco, S. The Payment Reform Landscape. Health Affairs Blog. http://healthaffairs.org/blog/2014/09/30/the-payment-reform-landscape-value-oriented-payment-jumps-and-yet/ (30 September 2014).
The Henry J. Kaiser Family Foundation. 2015 employer health benefits survey. http://kff.org/report-section/ehbs-2015-summary-of-findings/ (22 September 2015; accessed 28 November 2015).
Pew Research Center. Mobile technology fact sheet. http://www.pewinternet.org/fact-sheets/mobile-technology-fact-sheet/ (October, 2014; accessed 28 November 2015).
Pew Research Center. Broadband technology fact sheet. http://www.pewinternet.org/fact-sheets/broadband-technology-fact-sheet/ (September 2013; accessed 28 November 2015).
Centers for Disease Control and Prevention. 2014 national diabetes statistics report. http://www.cdc.gov/diabetes/data/statistics/2014StatisticsReport.html (Accessed 28 November 2015).
American Diabetes Association Standards of Medical Care in Diabetes—2016 (ADA, Washington, DC, 2016). http://care.diabetesjournals.org/content/suppl/2015/12/21/39.Supplement_1.DC2/2016-Standards-of-Care.pdf
Renders, C.M. et al. Cochrane Database Syst. Rev. 2001, CD001481 (2001).
Nathan, D.M. et al. Diabetes Care 30, 753–759 (2007).
Quinn, C.C. et al. Diabetes Care 34, 1934–1942 (2011).
Knowler, W.C. et al. N. Engl. J. Med. 346, 393–403 (2002).
Sepah, S.C., Jiang, L. & Peters, A.L. J. Med. Internet Res. 17, e92 (2015).
Centers for Disease Control and Prevention. Diabetes Prevention Recognition Program: registry of recognized programs. https://nccd.cdc.gov/DDT_DPRP/Registry.aspx (Accessed November 28, 2015).
Rice, J.B. et al. Diabetes Care 37, 651–658 (2014).
Centers for Disease Control and Prevention. Asthma. http://www.cdc.gov/asthma/ (Accessed 28 November 2015)
Centers for Disease Control and Prevention. Smoking and tobacco use. http://www.cdc.gov/tobacco/ (Accessed 28 November 2015)
Centers for Disease Control and Prevention. Chronic obstructive pulmonary disease (COPD). http://www.cdc.gov/copd/index.html (Accessed 28 November 2015).
Bricker, J.B. et al. Drug Alcohol Depend. 143, 87–94 (2014).
Brewer, J.A. et al. Drug Alcohol Depend. 119, 72–80 (2011).
Alzheimer's Association. 2015 Alzheimer's disease facts and figures. http://www.alz.org/facts/ (Accessed 13 January 2016).
Centers for Disease Control and Prevention. Attention-deficit/hyperactivity disorder (ADHD) data & statistics. http://www.cdc.gov/ncbddd/adhd/data.html (Accessed 13 January 2016).
Centers for Disease Control and Prevention. Autism spectrum disorder (ASD). Facts About ASD. http://www.cdc.gov/ncbddd/autism/facts.html (Accessed 13 January 2016).
30. Centers for Disease Control and Prevention. Stroke facts. http://www.cdc.gov/stroke/facts.htm (24 March 2015).
Anguera, J.A. et al. Nature 501, 97–101 (2013).
Cutler, A. et al. Game-Based Digital Intervention Improves Attention & Memory in Pediatric ADHD. Poster session presented at the American Academy of Child and Adolescent Psychiatry 62nd Annual Meeting, San Antonio, TX, USA, October 26–31, 2015.
Andersson, G., Cuijpers, P., Carlbring, P., Riper, H. & Hedman, E. World Psychiatry 13, 288–295 (2014).
Viswanathan, M. et al. Ann. Intern. Med. 157, 785–795 (2012).
Osterberg, L. & Blaschke, T. N. Engl. J. Med. 353, 487–497 (2005).
Iuga, A.O. & McGuire, M.J. Risk Manag. Healthc. Policy 7, 35–44 (2014).
Au-Yeung, K.Y. & DiCarlo, L. Int. J. Tuberc. Lung Dis. 16, 1498–1504 (2012).
Belknap, R. et al. PLoS One 8, e53373 (2013).
Boland, M.V. et al. JAMA Ophthalmol. 132, 845–850 (2014).
Elenko, E., Speier, A. & Zohar, D. Nat. Biotechnol. 33, 697–702 (2015).
Federal Trade Commission. Lumosity to pay $2 million to settle FTC deceptive advertising charges for Its “Brain Training” program. https://www.ftc.gov/news-events/press-releases/2016/01/lumosity-pay-2-million-settle-ftc-deceptive-advertising-charges (5 January 2016).
Federal Trade Commission. FTC approves final order barring company from making unsubstantiated claims related to products' “Brain Training” capabilities. https://www.ftc.gov/news-events/press-releases/2015/04/ftc-approves-final-order-barring-company-making-unsubstantiated (9 April 2015; accessed 13 January 2016).
Kish, L.J. & Topol, E.J. Nat. Biotechnol. 33, 921–924 (2015).
Federal Trade Commission. FTC cracks down on marketers of “Melanoma Detection” apps. http://www.ftc.gov/news-events/press-releases/2015/02/ftc-cracks-down-marketers-melanoma-detection-apps (23 February 2015).
National Institute of Mental Health. Annual total direct and indirect costs of serious mental illness. http://www.nimh.nih.gov/health/statistics/cost/index.shtml (Accessed 28 November 2015).
Gaskin, D.J. & Richard, P. J. Pain 13, 715–724 (2012).
J.C.K. is an advisor to Claritas Mind Sciences and to PureTech Health. E.E. and D.Z. are employed by PureTech, which has companies operating in the digital medicine area, including Akili Interactive Labs and Sonde Health, mentioned in the article.
About this article
Cite this article
Kvedar, J., Fogel, A., Elenko, E. et al. Digital medicine's march on chronic disease. Nat Biotechnol 34, 239–246 (2016) doi:10.1038/nbt.3495
Journal of Stroke (2019)
Short-term impact of PM2.5on contemporaneous asthma medication use: Behavior and the value of pollution reductions
Proceedings of the National Academy of Sciences (2019)
SMURF: Systematic Methodology for Unveiling Relevant Factors in Retrospective Data on Chronic Disease Treatments
IEEE Access (2019)
Association Between Improvement in Baseline Mood and Long-Term Use of a Mindfulness and Meditation App: Observational Study
JMIR Mental Health (2019)