Can CRISPR-Cas9 gene drives curb malaria?

Gene drives in mosquitoes to reduce the spread of malaria move closer, though technical and regulatory hurdles remain.

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Figure 1: Nuclease-based gene drives.

Katie Vicari/Nature Publishing Group

References

  1. 1

    Gantz, V.M. & Bier, E. Science 348, 442–444 (2015).

    CAS  Article  Google Scholar 

  2. 2

    Hammond, A. et al. Nat. Biotechnol. 34, 78–83 (2016).

    CAS  Article  Google Scholar 

  3. 3

    Gantz, V.M. et al. Proc. Natl. Acad. Sci. USA 112, E6736–E6743 (2015).

    CAS  Article  Google Scholar 

  4. 4

    Alphey, L. Annu. Rev. Entomol. 59, 205–224 (2014).

    CAS  Article  Google Scholar 

  5. 5

    Carvalho, D.O. et al. PLoS Negl. Trop. Dis. 9, e0003864 (2015).

    Article  Google Scholar 

  6. 6

    Burt, A. & Trivers, R. Genes in Conflict: The Biology of Selfish Genetic Elements (Belknap Press, Harvard University Press, 2006).

    Google Scholar 

  7. 7

    Burt, A. Proc. R. Soc. Lond. B 270, 921–928 (2003).

    CAS  Article  Google Scholar 

  8. 8

    Deredec, A., Burt, A. & Godfray, H.C. Genetics 179, 2013–2026 (2008).

    Article  Google Scholar 

  9. 9

    Galizi, R. et al. Nat. Commun. 5, 3977 (2014).

    CAS  Article  Google Scholar 

  10. 10

    Davis, S., Bax, N. & Grewe, P. J. Theor. Biol. 212, 83–98 (2001).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Luke Alphey.

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Competing interests

LA is a Visiting Professor at the University of Oxford and has equity interest in Intrexon Inc. Both organisations have intellectual property in the area of genetic pest management. LA's research program at the Pirbright Institute aims to develop various genetic pest management approaches with funding from various sources, including BBSRC, Horizon2020 and the Wellcome Trust.

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Alphey, L. Can CRISPR-Cas9 gene drives curb malaria?. Nat Biotechnol 34, 149–150 (2016). https://doi.org/10.1038/nbt.3473

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