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Cas9-triggered chain ablation of cas9 as a gene drive brake

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Figure 1: Schematics and proof of principle of CATCHA.

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Acknowledgements

We thank D. Luginbuhl for generating transgenic flies, F. Port for providing gRNA flies, and J. Luo, T. Mosca, X. Wang, J. Li and J. Lui for advice and critical comments. This study was supported by an NIH grant (R01-DC005982) to L.L. X.J.G. was supported by an Enlight Foundation Interdisciplinary Fellowship. L.L. is an HHMI investigator.

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Correspondence to Liqun Luo.

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Wu, B., Luo, L. & Gao, X. Cas9-triggered chain ablation of cas9 as a gene drive brake. Nat Biotechnol 34, 137–138 (2016). https://doi.org/10.1038/nbt.3444

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