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Scaling up phenotyping studies

Nature Biotechnology volume 33, pages 1150–1151 (2015)Cite this article

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A well-designed mouse phenotyping study adds to the catalog of mammalian gene function.

A coordinated, global initiative to knock out every protein-coding gene in the mouse, one by one, is beginning to provide answers to fundamental questions about how genes function. A recent mouse phenotyping study reported in Nature Genetics by Hrabě de Angelis et al.1 from the European Mouse Disease Clinic (EUMODIC) consortium gives us a front-row view of this effort. The authors present results from 20 broad-based physiologic screens completed for 320 of these knockout lines. By investigating the technical variation of results generated at different centers and developing a sophisticated statistical model that improves reproducibility across centers, they reveal new and surprising insights into mammalian genome function and uncover extensive pleiotropic effects.

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Figure 1: Assessing the reproducibility of reference lines across multiple centers.

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  1. Karen L. Svenson is at The Jackson Laboratory, Bar Harbor, Maine, USA.

    Karen L Svenson

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  1. Karen L Svenson
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Correspondence to Karen L Svenson.

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The author declares no competing financial interests.

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Svenson, K. Scaling up phenotyping studies. Nat Biotechnol 33, 1150–1151 (2015). https://doi.org/10.1038/nbt.3400

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