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Gene drive overdrive

Nature Biotechnology volume 33, pages 1019–1021 (2015)Cite this article

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The recent publication of a simple procedure for creating a CRISPR-Cas9-mediated gene drive has some researchers sounding the alarm. What are the risks to populations in the wild and what precautions are necessary? Laura DeFrancesco investigates.

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References

  1. Curtis, C.F. Nature 218, 368–369 (1968).

    Article  CAS  Google Scholar 

  2. Windbichler, N. et al. Nature 473, 212–215 (2011).

    Article  CAS  Google Scholar 

  3. Gantz, V.M. & Bier, E. Science 348, 442–444 (2015).

    Article  CAS  Google Scholar 

  4. Esvelt, K. et al. Elife e03401 (2014).

  5. Marshall, J.M. & Hay, B.A. PLoS One 9, e102694 (2014).

    Article  Google Scholar 

  6. Oye, K.A. et al. Science 345, 626–628 (2014).

    Article  CAS  Google Scholar 

  7. Lunshof, J. Nature 521, 127 (2015).

    Article  CAS  Google Scholar 

  8. Akbari, O.S. et al. Science 349, 927–929 (2015).

    Article  CAS  Google Scholar 

  9. Galizi, R. et al. Nat. Commun. 5, 3977 (2014).

    Article  CAS  Google Scholar 

  10. Engels, W.R. BioEssays 14, 681–686 (1992).

    Article  CAS  Google Scholar 

  11. DiCarlo, J.E. et al. Preprint at http://biorxiv.org/content/early/2015/03/19/013896 (2015).

  12. Department of Health and Human Services. NIH guidelines for research involving recombinant or synthetic nucleic acid molecules. http://osp.od.nih.gov/office-biotechnology-activities/biosafety/nih-guidelines (HHS, November 2013).

  13. ASTMH-ACME Draft Committee. Arthropod Containment Guidelines (ver. 3.1). http://www.astmh.org/AM/Template.cfm?Section=ACME&Template=/CM/ContentDisplay.cfm&ContentID=1444 (The American Committee of Medical Entomology of the American Society for Tropical Medicine and Hygiene; 20 December 2001).

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Gene drive overdrive. Nat Biotechnol 33, 1019–1021 (2015). https://doi.org/10.1038/nbt.3361

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