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Change history
07 August 2015
In the version of this article initially published, a footnote and boldface type were omitted from Table 1. The column heading 'Correlation and P-values' should have read 'Correlation'. The footnote should have read “Bold: significant correlation coefficients, P < 0.01.” In the body of the table, P-values were present in all cells, but these should have been omitted and bold face should have been used to indicate significant correlation coefficients. The errors have been corrected in the HTML and PDF versions of the article.
References
Merton, R.C. Bell J. Econ. 4, 141–183 (1973).
Black, F. & Scholes, M. J. Polit. Econ. 81, 637–654 (1973).
Gross, C.P., Anderson, G.F. & Powe, N.R. N. Engl. J. Med. 340, 1881–1887 (1999).
Gillum, L.A. et al. PLoS ONE 6, e16837 (2011).
Sampat, B.N., Buterbaugh, K. & Perl, M. Milbank Q. 91, 163–185 (2013).
Vanderelst, D. & Speybroeck, N. J. Informetrics 7, 240–247 (2013).
Evans, J.A., Shim, J.-M. & Ioannidis, J.P. PLoS ONE 9, e90147 (2014).
Murray, C. Bull. World Health Organ. 72, 429–445 (1994).
Reiss, J. & Kitcher, P. THEORIA 24, 263–282 (2010).
Kleinbaum, D., Kupper, L., Nizam, A. & Rosenberg, E. Applied regression analysis and other multivariable methods (Cengage Learning, 2013).
Vanderelst, D. & Speybroeck, N. PLoS Negl. Trop. Dis. 4, e576 (2010).
Acknowledgements
We are grateful to R. Kumar and H. Madsen for helpful comments on earlier versions of the manuscript. This work was supported by US National Institutes of Health grants 1P50MH094267 and U01HL108634-01 (A.R.), GlaxoSmithKline funds (L.Y., Y.L., S.G.) and the University of North Carolina at Charlotte Faculty Research Grant (L.Y.).
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S.G. is an employee of GlaxoSmithKline.
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Supplementary Data; Supplementary Tables 1–5 Supplementary Figure 1 (PDF 692 kb)
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Yao, L., Li, Y., Ghosh, S. et al. Health ROI as a measure of misalignment of biomedical needs and resources. Nat Biotechnol 33, 807–811 (2015). https://doi.org/10.1038/nbt.3276
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DOI: https://doi.org/10.1038/nbt.3276
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