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Opportunities for drug repositioning from phenome-wide association studies

Nature Biotechnology volume 33, pages 342345 (2015) | Download Citation

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Acknowledgements

This project was supported in part by US National Center for Advancing Translational Sciences grant UL1TR000427 and National Library of Medicine grant 1K22LM011938. M.R.-M. was funded through philanthropic support of the Marshfield Clinic Research Foundation's “Dr. John Melski Endowed Physician Scientist” award granted to S.M.L. We thank J. Denny and colleagues for making the PheWAS catalog available online. We also thank D. Wall for project management and R. Stankowski for critical review, editing and comments.

Author information

Author notes

    • Majid Rastegar-Mojarad
    •  & Simon M Lin

    Present addresses: Biomedical Statistics and Bioinformatics, Mayo Clinic, Rochester, Minnesota, USA and Nationwide Children's Hospital, Columbus, Ohio, USA.

Affiliations

  1. Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA.

    • Majid Rastegar-Mojarad
    • , Zhan Ye
    •  & Simon M Lin
  2. School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA.

    • Jill M Kolesar
  3. Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA.

    • Scott J Hebbring

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Scott J Hebbring.

Supplementary information

PDF files

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    Supplementary Text and Figures

    Supplementary Figures 1 and 2

Excel files

  1. 1.

    Supplementary Table 1

    Complete list of drug-disease pairs including PheWAS association results, gene target, phenotype, candidate drug, significance category, number of supporting references from Medline abstracts and the Clinical Trial Registry, and overlap with GWAS results.

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DOI

https://doi.org/10.1038/nbt.3183

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