Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Drugging the gut microbiome

An Erratum to this article was published on 09 May 2017

This article has been updated

Using conventional drug discovery and novel synthetic biology approaches, some investigators and companies are mining our resident microbes and their metabolites for targets in small-molecule drug programs. Ken Garber reports.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: The metabolites produced by gut bacterial fermentation of dietary fiber induce Tregs and dampen inflammation.

Change history

  • 12 October 2016

    In the version of this article initially published, on p.231, left-hand column, the maker of linaclotide was said to be Redwood rather than Ironwood Pharmaceuticals. In addition, linaclotide is no longer referred to as a “homolog of the enterotoxin peptides,” but as “similar to the enterotoxin peptides,” and it has been clarified to be “rationally designed.” The errors have been corrected in the HTML and PDF versions of the article.


  1. Wang, Z. et al. Nature 472, 57–63 (2011).

    CAS  Article  Google Scholar 

  2. van Nood, E. et al. N. Engl. J. Med. 368, 407–415 (2013).

    CAS  Article  Google Scholar 

  3. Hsiao, E.Y. et al. Cell 155, 1451–1463 (2013).

    CAS  Article  Google Scholar 

  4. Mazmanian, S.K. et al. Cell 122, 107–118 (2005).

    CAS  Article  Google Scholar 

  5. Atarashi, K. et al. Nature 500, 232–236 (2013).

    CAS  Article  Google Scholar 

  6. Trompette, A. et al. Nat. Med. 20, 159–166 (2014).

    CAS  Article  Google Scholar 

  7. Chang, P.V. et al. Proc. Natl. Acad. Sci. USA 111, 2247–2252 (2014).

    CAS  Article  Google Scholar 

  8. Yoshimoto, S. et al. Nature 499, 97–101 (2013).

    CAS  Article  Google Scholar 

  9. Donia, M.S. et al. Cell 158, 1402–1414 (2014).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Garber, K. Drugging the gut microbiome. Nat Biotechnol 33, 228–231 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing