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Drugging the gut microbiome

An Erratum to this article was published on 09 May 2017

This article has been updated

Using conventional drug discovery and novel synthetic biology approaches, some investigators and companies are mining our resident microbes and their metabolites for targets in small-molecule drug programs. Ken Garber reports.

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Figure 1: The metabolites produced by gut bacterial fermentation of dietary fiber induce Tregs and dampen inflammation.

Change history

  • 12 October 2016

    In the version of this article initially published, on p.231, left-hand column, the maker of linaclotide was said to be Redwood rather than Ironwood Pharmaceuticals. In addition, linaclotide is no longer referred to as a “homolog of the enterotoxin peptides,” but as “similar to the enterotoxin peptides,” and it has been clarified to be “rationally designed.” The errors have been corrected in the HTML and PDF versions of the article.


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Garber, K. Drugging the gut microbiome. Nat Biotechnol 33, 228–231 (2015).

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