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We would like to thank N.E. Sanjana, S. Konermann, M.D. Brigham, A. Trevino, F.A. Ran and W. Yan for technical assistance, S. Jones, M. Heidenreich and K. Zheng for editing and members of the Zhang laboratory for discussion, support and advice. F.Z. is supported by the National Institute of Mental Health (NIMH) through a National Institutes of Health (NIH) Director's Pioneer Award (DP1-MH100706), the National Institute of Neurological Disorders and Stroke (NINDS) through an NIH Transformative R01 grant (R01-NS 07312401), National Science Foundation (NSF) Waterman Award, the Keck, Damon Runyon, Searle Scholars, Klingenstein, Vallee, Merkin and Simons Foundations, and Bob Metcalfe, New York Stem Cell Foundation. F.Z. is a New York Stem Cell Foundation Robertson Investigator. CRISPR reagents are available to the academic community through Addgene, and associated protocols, support forum and computational tools are available via the Zhang laboratory website (http://www.genome-engineering.org).
Feng Zhang is a scientific advisor of Editas Medicine and of Horizon Discovery.
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Zetsche, B., Volz, S. & Zhang, F. A split-Cas9 architecture for inducible genome editing and transcription modulation. Nat Biotechnol 33, 139–142 (2015). https://doi.org/10.1038/nbt.3149
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