Delivery of siRNA into cells is achieved by neutralizing the negative charge of the phosphate backbone in a reversible manner.
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Change history
29 April 2015
In the version of this article initially published, in two instances molecules were misidentified in the text. The last sentence in the legend of Figure 1 should have read, “a charged phosphodiester,” rather than “a phosphatediester.” On p.1197, third column, first paragraph, “intracellular phosphodiesterases….” should have read, “intracellular thioesterases….” The errors have been corrected in the HTML and PDF versions of the article.
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Khvorova, A., Osborn, M. & Hassler, M. Taking charge of siRNA delivery. Nat Biotechnol 32, 1197–1198 (2014). https://doi.org/10.1038/nbt.3091
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DOI: https://doi.org/10.1038/nbt.3091
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