Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Closing in on pancreatic beta cells

Differentiation of human pluripotent stem cells toward pancreatic beta cells yields cells of increased maturity.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Rezania et al.4 describe the differentiation of hPSCs toward pancreatic beta cells.


  1. Assady, S. et al. Diabetes 50, 1691–1697 (2001).

    Article  CAS  Google Scholar 

  2. Kroon, E. et al. Nat. Biotechnol. 26, 443–452 (2008).

    Article  CAS  Google Scholar 

  3. Hebrok, M. Cold Spring Harb. Perspect. Med. 2, a007674 (2012).

    Article  Google Scholar 

  4. Rezania, A. et al. Nat. Biotechnol. 32, 1121–1133 (2014).

    Article  CAS  Google Scholar 

  5. Barton, F.B. et al. Diabetes Care 35, 1436–1445 (2012).

    Article  CAS  Google Scholar 

  6. Jennings, R.E. et al. Diabetes 62, 3514–3522 (2013).

    Article  CAS  Google Scholar 

  7. Mukhi, S., Horb, M.E. & Brown, D.D. Dev. Biol. 328, 384–391 (2009).

    Article  CAS  Google Scholar 

  8. Aguayo-Mazzucato, C. et al. Diabetes 62, 1569–1580 (2013).

    Article  CAS  Google Scholar 

  9. Stanger, B.Z. & Hebrok, M. Gastroenterology 144, 1170–1179 (2013).

    Article  Google Scholar 

  10. Rezania, A. et al. Diabetes 61, 2016–2029 (2012).

    Article  CAS  Google Scholar 

  11. Solar, M. et al. Dev. Cell 17, 849–860 (2009).

    Article  CAS  Google Scholar 

  12. Rezania, A. et al. Diabetes 60, 239–247 (2011).

    Article  CAS  Google Scholar 

  13. Blum, B. et al. eLife 3, e02809 (2014).

    Article  Google Scholar 

  14. Pagliuca, F.W. et al. Cell 159, 428–439 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Neil Hanley.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hanley, N. Closing in on pancreatic beta cells. Nat Biotechnol 32, 1100–1102 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research