Human pluripotent stem cells can be coaxed into a pure population of definitive hematopoietic cells.
Access options
Subscribe to Journal
Get full journal access for 1 year
$59.00
only $4.92 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
from$8.99
All prices are NET prices.

Debbie Maizels/Nature Publishing Group
References
- 1
Slukvin, I.I. Blood 122, 4035–4046 (2013).
- 2
Sturgeon, C.M., Ditad, A. & Awong, G. Nat. Biotechnol. 32, 554–561 (2014).
- 3
Palis, J. Front. Physiol. 5, 3 (2014).
- 4
Schulz, C. et al. Science 336, 86–90 (2012).
- 5
Böiers, C. et al. Cell Stem Cell 13, 535–548 (2013).
- 6
Yoshimoto, M. et al. Blood 119, 5706–5714 (2012).
- 7
Swiers, G. et al. Nat. Commun. 4, 2924 (2013).
- 8
Kennedy, M. et al. Cell Rep. 2, 1722–1735 (2012).
- 9
Lancrin, C. et al. Nature 457, 892–895 (2009).
- 10
Chong, D.C., Koo, Y., Xu, K., Fu, S. & Cleaver, O. Dev. Dyn. 240, 2153–2165 (2011).
- 11
Corada, M. et al. Nat. Commun. 4, 2609 (2013).
- 12
Lucitti, J.L. et al. Development 134, 3317–3326 (2007).
Author information
Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Yoder, M. Inducing definitive hematopoiesis in a dish. Nat Biotechnol 32, 539–541 (2014). https://doi.org/10.1038/nbt.2929
Published:
Issue Date:
Further reading
-
The role of m6A modification in the biological functions and diseases
Signal Transduction and Targeted Therapy (2021)
-
Dynamic regulation of GATA2 in fate determination in hematopoiesis: possible approach to hPSC-derived hematopoietic stem/progenitor cells
Blood Science (2020)
-
Hedgehog–FGF signaling axis patterns anterior mesoderm during gastrulation
Proceedings of the National Academy of Sciences (2020)
-
Distinct Waves from the Hemogenic Endothelium Give Rise to Layered Lymphoid Tissue Inducer Cell Ontogeny
Cell Reports (2020)
-
Modeling blood diseases with human induced pluripotent stem cells
Disease Models & Mechanisms (2019)