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Simply better glycoproteins

Reducing the glycan heterogeneity of recombinant proteins may improve the efficacy of biopharmaceuticals.

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Figure 1: GlycoDelete system.

References

  1. Lepenies, B., Yin, J. & Seeberger, P.H. Curr. Opin. Chem. Biol. 14, 404–411 (2010).

    Article  CAS  Google Scholar 

  2. Meuris, L. et al. Nat. Biotechnol. 32, 485–487 (2014).

    Article  CAS  Google Scholar 

  3. Rich, J.R. & Withers, S.G. Nat. Chem. Biol. 5, 206–215 (2009).

    Article  CAS  Google Scholar 

  4. Schwarz, F. et al. Nat. Chem. Biol. 6, 264–266 (2010).

    Article  CAS  Google Scholar 

  5. Hamilton, S.R. et al. Science 313, 1441–1443 (2006).

    Article  CAS  Google Scholar 

  6. Castilho, A. et al. Glycobiology 21, 813–823 (2011).

    Article  CAS  Google Scholar 

  7. Aumiller, J.J., Mabashi-Asazuma, H., Hillar, A., Shi, X. & Jarvis, D.L. Glycobiology 22, 417–428 (2012).

    Article  CAS  Google Scholar 

  8. Wang, Z. et al. Science 341, 379–383 (2013).

    Article  CAS  Google Scholar 

  9. Wang, P. et al. Science 342, 1357–1360 (2013).

    Article  CAS  Google Scholar 

  10. Seeberger, P.H. & Werz, D.B. Nature 446, 1046–1051 (2007).

    Article  CAS  Google Scholar 

  11. Reeves, P.J., Callewaert, N., Contreras, R. & Khorana, H.G. Proc. Natl. Acad. Sci. USA 99, 13419–13424 (2002).

    Article  CAS  Google Scholar 

  12. Lepenies, B., Lee, J. & Sonkaria, S. Adv. Drug Deliv. Rev. 65, 1271–1281 (2013).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Bernd Lepenies or Peter H Seeberger.

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Lepenies, B., Seeberger, P. Simply better glycoproteins. Nat Biotechnol 32, 443–445 (2014). https://doi.org/10.1038/nbt.2893

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