Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Casting light on pain

Optogenetic methods to control nociceptors open up a wealth of potential applications in pain research and therapy.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Optogenetic control of peripheral pain pathways.

Katie Vicari


  1. Iyer, S.M. et al. Nat. Biotechnol. 32, 274–278 (2014).

  2. Daou, I. et al. J. Neurosci. 33, 18631–18640 (2013).

    CAS  Article  Google Scholar 

  3. Towne, C., Pertin, M., Beggah, A.T., Aebischer, P. & Decosterd, I. Mol. Pain 5, 52 (2009).

    Article  Google Scholar 

  4. Stirling, L.C. et al. Pain 113, 27–36 (2005).

    CAS  Article  Google Scholar 

  5. Madisen, L. et al. Nat. Neurosci. 15, 793–802 (2012).

    CAS  Article  Google Scholar 

  6. Woolf, C.J. Nature 306, 686–688 (1983).

    CAS  Article  Google Scholar 

  7. Browne, L.E. et al. Proc. Natl. Acad. Sci. USA 111, 521–526 (2014).

    CAS  Article  Google Scholar 

  8. Williams, J.C. & Denison, T. Sci. Transl. Med. 5, 177ps176 (2013).

    Article  Google Scholar 

  9. Yizhar, O., Fenno, L.E., Davidson, T.J., Mogri, M. & Deisseroth, K. Neuron 71, 9–34 (2011).

    CAS  Article  Google Scholar 

  10. Szobota, S. & Isacoff, E.Y. Optical control of neuronal activity. Annu. Rev. Biophys. 39, 329–348 (2010).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Clifford J Woolf.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Browne, L., Woolf, C. Casting light on pain. Nat Biotechnol 32, 240–241 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing