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Of snowflakes and natural killer cell subsets

Mass cytometric analysis reveals a remarkable and unanticipated degree of phenotypic heterogeneity among human peripheral blood natural killer cells.

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Figure 1: Subsets of subsets of subsets.

References

  1. Horowitz, A. et al. Sci. Transl. Med. 5, 208ra145 (2013).

    Article  Google Scholar 

  2. Loken, M.R., Parks, D.R. & Herzenberg, L.A. J. Histochem. Cytochem. 25, 899–907 (1977).

    Article  CAS  Google Scholar 

  3. Parks, D.R., Hardy, R.R. & Herzenberg, L.A. Cytometry 5, 159–168 (1984).

    Article  CAS  Google Scholar 

  4. Lanier, L.L. & Loken, M.R. J. Immunol. 132, 151–156 (1984).

    CAS  PubMed  Google Scholar 

  5. Bendall, S.C., Nolan, G.P., Roederer, M. & Chattopadhyay, P.K. Trends Immunol. 33, 323–332 (2012).

    Article  CAS  Google Scholar 

  6. Bendall, S.C. et al. Science 332, 687–696 (2011).

    Article  CAS  Google Scholar 

  7. Newell, E.W., Sigal, N., Bendall, S.C., Nolan, G.P. & Davis, M.M. Immunity 36, 142–152 (2012).

    Article  CAS  Google Scholar 

  8. Chng, W.J., Tan, G.B. & Kuperan, P. Clin. Diagn. Lab. Immunol. 11, 168–173 (2004).

    PubMed  PubMed Central  Google Scholar 

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Acknowledgements

L.L.L. is an American Cancer Society Professor and funded by US National Institutes of Health grants AI066897 and AI068129.

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Correspondence to Lewis L Lanier.

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The author declares no competing financial interests.

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Lanier, L. Of snowflakes and natural killer cell subsets. Nat Biotechnol 32, 140–142 (2014). https://doi.org/10.1038/nbt.2810

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