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Clinical development success rates for investigational drugs

Nature Biotechnology volume 32, pages 4051 (2014) | Download Citation


The most comprehensive survey of clinical success rates across the drug industry to date shows productivity may be even lower than previous estimates.

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This research was supported by Sagient Research Systems and the Biotechnology Industry Organization (BIO). The authors are indebted to the analysts at BioMedTracker who have collected these data. We would also like to thank our colleagues at BIO and BioMedTracker for their input and advice in the development of this study. The authors are solely responsible for the design, conduct and analysis of the study, and the conclusions that are drawn. The opinions expressed in this article are those of the authors and do not necessarily reflect the views of their employers.

Author information


  1. Michael Hay and Jesse Rosenthal are at BioMedTracker, Sagient Research Systems, San Diego, California, USA

    • Michael Hay
    •  & Jesse Rosenthal
  2. David W. Thomas and Celia Economides are at the Biotechnology Industry Organization (BIO), Washington, DC, USA

    • David W Thomas
    •  & Celia Economides
  3. John L. Craighead is at Biotech Strategy & Analytics, Rockville, Maryland, USA.

    • John L Craighead


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Competing interests

M.H. and J.R. are employees of Sagient Research Systems, Inc. D.W.T. is an employee of Biotechnology Industry Organization. J.L.C. is the owner of Biotech Strategy & Analytics. C.E. is an employee of Prosensa Holding N.V.

Corresponding author

Correspondence to Michael Hay.

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