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Genetically encoded voltage sensor goes live

A genetically encoded voltage indicator enables robust optical recording of membrane voltage changes in the fly brain.

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Figure 1: Cao et al.1 demonstrate genetically targeted, single-trial voltage imaging in the intact brain of Drosophila in vivo.

Marina Corral Spence


  1. Cao, G. et al. Cell 154, 904–913 (2013).

    Article  CAS  Google Scholar 

  2. Jin, L. et al. Neuron 75, 779–785 (2012).

    Article  CAS  Google Scholar 

  3. Chen, T.-W. et al. Nature 499, 295–300 (2013).

    Article  CAS  Google Scholar 

  4. Scanziani, M. & Häusser, M. Nature 461, 930–939 (2009).

    Article  CAS  Google Scholar 

  5. Grienberger, C. & Konnerth, A. Neuron 73, 862–885 (2012).

    Article  CAS  Google Scholar 

  6. Mutoh, H. & Knöpfel, T. Pflügers Arch. Eur. J. Phys. 465, 361–371 (2013).

    Article  CAS  Google Scholar 

  7. Ahrens, K.F., Heider, B., Lee, H., Isacoff, E.Y. & Siegel, R.M. Front. Neural Circuits 6, 15 (2012).

    Article  Google Scholar 

  8. Akemann, W. et al. Sci. Reports 3, 2231 (2013).

    Google Scholar 

  9. Akemann, W., Mutoh, H., Perron, A., Rossier, J. & Knöpfel, T. Nat. Methods 7, 643–649 (2010).

    Article  CAS  Google Scholar 

  10. Kuhn, B., Denk, W. & Bruno, R.M. Proc. Natl. Acad. Sci. USA 105, 7588–7593 (2008).

    Article  CAS  Google Scholar 

  11. Miller, E.W. et al. Proc. Natl. Acad. Sci. USA 109, 2114–2119 (2012).

    Article  CAS  Google Scholar 

  12. Ziv, Y. et al. Nat. Neurosci. 16, 264–266 (2013).

    Article  CAS  Google Scholar 

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Correspondence to Karl Deisseroth.

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Marshel, J., Deisseroth, K. Genetically encoded voltage sensor goes live. Nat Biotechnol 31, 994–995 (2013).

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