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References
O'Neill, M.J. et al. Drug Discov. Today 16, 203–218 (2011).
Forbes, D.C. & Peppas, N.A. J. Control. Release 162, 438–445 (2012).
Burnett, J.C. & Rossi, J.J. Chem. Biol. 19, 60–71 (2012).
Timmons, L. & Fire, A. Nature 395, 854 (1998).
Baum, J. et al. Nat. Biotechnol. 25, 1322–1326 (2007).
Mao, Y.B. et al. Nat. Biotechnol. 25, 1307–1313 (2007).
Nuez, I. & Félix, M.A. PLoS One 7, e29811 (2012).
Terenius, O. et al. J. Insect Physiol. 57, 231–245 (2011).
Zhang, L. et al. Cell Res. 22, 107–126 (2012).
Zhang, Y. et al. BMC Genomics 13, 381 (2012).
Ivashuta, S.I. et al. Food Chem. Toxicol. 47, 353–360 (2009).
Heisel, S.E. et al. PLoS ONE 3, e2871 (2008).
Yu, B. et al. Science 307, 932–935 (2005).
Munafó, D.B. & Robb, G.B. RNA 16, 2537–2552 (2010).
Ryu, M.H. et al. Nutrition 21, 543–552 (2005).
Zhou, X.H. et al. Food Chem. Toxicol. 49, 3112–3118 (2011).
Zhou, X.H. et al. Food Chem. Toxicol. 50, 1902–1910 (2012).
Acknowledgements
The authors wish to thank J. Heard (Monsanto) for initiating collaboration work on this project, and D. Ader, R. Kerstetter, M. Huang and T. Samanta for small RNA sequencing.
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The authors of this publication are employed by companies that carry out research and development of products leveraging small RNAs.
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Dickinson, B., Zhang, Y., Petrick, J. et al. Lack of detectable oral bioavailability of plant microRNAs after feeding in mice. Nat Biotechnol 31, 965–967 (2013). https://doi.org/10.1038/nbt.2737
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DOI: https://doi.org/10.1038/nbt.2737
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