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Lack of detectable oral bioavailability of plant microRNAs after feeding in mice

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Figure 1: Plasma LDL levels and LDLRAP1 protein levels in mice fed synthetic chow or rice-containing chows.


  1. O'Neill, M.J. et al. Drug Discov. Today 16, 203–218 (2011).

    Article  CAS  Google Scholar 

  2. Forbes, D.C. & Peppas, N.A. J. Control. Release 162, 438–445 (2012).

    Article  CAS  Google Scholar 

  3. Burnett, J.C. & Rossi, J.J. Chem. Biol. 19, 60–71 (2012).

    Article  CAS  Google Scholar 

  4. Timmons, L. & Fire, A. Nature 395, 854 (1998).

    Article  CAS  Google Scholar 

  5. Baum, J. et al. Nat. Biotechnol. 25, 1322–1326 (2007).

    Article  CAS  Google Scholar 

  6. Mao, Y.B. et al. Nat. Biotechnol. 25, 1307–1313 (2007).

    Article  CAS  Google Scholar 

  7. Nuez, I. & Félix, M.A. PLoS One 7, e29811 (2012).

    Article  CAS  Google Scholar 

  8. Terenius, O. et al. J. Insect Physiol. 57, 231–245 (2011).

    Article  CAS  Google Scholar 

  9. Zhang, L. et al. Cell Res. 22, 107–126 (2012).

    Article  CAS  Google Scholar 

  10. Zhang, Y. et al. BMC Genomics 13, 381 (2012).

    Article  CAS  Google Scholar 

  11. Ivashuta, S.I. et al. Food Chem. Toxicol. 47, 353–360 (2009).

    Article  CAS  Google Scholar 

  12. Heisel, S.E. et al. PLoS ONE 3, e2871 (2008).

    Article  Google Scholar 

  13. Yu, B. et al. Science 307, 932–935 (2005).

    Article  CAS  Google Scholar 

  14. Munafó, D.B. & Robb, G.B. RNA 16, 2537–2552 (2010).

    Article  Google Scholar 

  15. Ryu, M.H. et al. Nutrition 21, 543–552 (2005).

    Article  CAS  Google Scholar 

  16. Zhou, X.H. et al. Food Chem. Toxicol. 49, 3112–3118 (2011).

    Article  CAS  Google Scholar 

  17. Zhou, X.H. et al. Food Chem. Toxicol. 50, 1902–1910 (2012).

    Article  CAS  Google Scholar 

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The authors wish to thank J. Heard (Monsanto) for initiating collaboration work on this project, and D. Ader, R. Kerstetter, M. Huang and T. Samanta for small RNA sequencing.

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Correspondence to Sergey Ivashuta or William S Marshall.

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The authors of this publication are employed by companies that carry out research and development of products leveraging small RNAs.

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Supplementary Figures 1–5, Supplementary Tables 1–4 and Supplementary Methods (PDF 174 kb)

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Dickinson, B., Zhang, Y., Petrick, J. et al. Lack of detectable oral bioavailability of plant microRNAs after feeding in mice. Nat Biotechnol 31, 965–967 (2013).

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