Can methylation be the key to challenging the interpretation of existing gene patent claims? And can a novel PCR method be used to enable the sequencing of hundreds of genes?
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We would like to thank C. Gunter, T. Harkins, S. Grimmond and R. McKernan for valuable editorial advice. We would like to thank E. Dimalantis for constructive discussions regarding MspJI.
The authors are employed by Courtagen Life Sciences, which is a CLIA and CAP-certified next-generation DNA sequencing facility. The company sequences gene panels and exomes of children with mitochondrial disease, epilepsy and autism. The opinions expressed by the authors on gene patents are their own and may not reflect those of Courtagen.
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McKernan, K., Spangler, J., Helbert, Y. et al. DREAMing of a patent-free human genome for clinical sequencing. Nat Biotechnol 31, 884–887 (2013). https://doi.org/10.1038/nbt.2703
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