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Targeted genome modification of crop plants using a CRISPR-Cas system

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Figure 1: Genome editing in rice and wheat using an engineered type II CRISPR-Cas system.
Figure 2: HDR-mediated genome modification in rice protoplasts.


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This work was supported by the National Natural Science Foundation of China (201263, 383601 and 31200273), the Ministry of Agriculture of China (2011ZX08002-004 and 2013ZX08010-002) and Chinese Academy of Sciences (KSCX2-EW-N-06, KSCX2-EW-J-6). We thank X. Wang for bioinformatics analysis.

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Correspondence to Jin-Long Qiu or Caixia Gao.

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Shan, Q., Wang, Y., Li, J. et al. Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol 31, 686–688 (2013).

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