Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Defining the path to hematopoietic stem cells

New insights into hemogenic endothelium will facilitate efforts to produce hematopoietic stem cells in vitro.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: A model depicting the development of hemogenic endothelium from PSCs.


  1. Choi, K.D. et al. Cell Reports 2, 553–567 (2012).

    Article  CAS  Google Scholar 

  2. Rafii, S. et al. Blood 121, 770–780 (2013).

    Article  CAS  Google Scholar 

  3. Nakajima-Takagi, Y. et al. Blood 121, 447–458 (2013).

    Article  CAS  Google Scholar 

  4. Kim, P.G. et al. Proc. Natl. Acad. Sci. USA 110, E141–E150 (2013).

    Article  CAS  Google Scholar 

  5. Kennedy, M. et al. Cell Reports 2, 1722–1735 (2012).

    Article  CAS  Google Scholar 

  6. Lee, D. et al. Cell Stem Cell 2, 497–507 (2008).

    Article  CAS  Google Scholar 

  7. Medvinsky, A., Rybtsov, S. & Taoudi, S. Development 138, 1017–1031 (2011).

    Article  CAS  Google Scholar 

  8. Antas, V.I., Al-Drees, M.A., Prudence, A.J., Sugiyama, D. & Fraser, S.T. Int. J. Biochem. Cell Biol. 45, 692–695 (2013).

    Article  CAS  Google Scholar 

  9. Choi, E. et al. Stem Cells 30, 2297–2308 (2012).

    Article  CAS  Google Scholar 

  10. Chen, M.J., Yokomizo, T., Zeigler, B.M., Dzierzak, E. & Speck, N.A. Nature 457, 887–891 (2009).

    Article  CAS  Google Scholar 

  11. Lancrin, C. et al. Nature 457, 892–895 (2009).

    Article  CAS  Google Scholar 

  12. Kaimakis, P., Crisan, M. & Dzierzak, E. Biochim. Biophys. Acta 1830, 2395–2403 (2013).

    Article  CAS  Google Scholar 

  13. Adamo, L. et al. Nature 459, 1131–1135 (2009).

    Article  CAS  Google Scholar 

  14. Fitch, S.R. et al. Cell Stem Cell 11, 554–566 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Gordon Keller.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sturgeon, C., Ditadi, A., Clarke, R. et al. Defining the path to hematopoietic stem cells. Nat Biotechnol 31, 416–418 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing