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RNA guides genome engineering

The Cas9 endonuclease is reprogrammed by RNAs for site-specific modification of eukaryotic and microbial genomes.

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Figure 1: Customizable molecular scissors.

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Correspondence to Toni Cathomen.

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Mussolino, C., Cathomen, T. RNA guides genome engineering. Nat Biotechnol 31, 208–209 (2013). https://doi.org/10.1038/nbt.2527

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