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Cardiac regenerative medicine 2.0

The key challenge in the field of molecular and cell-based therapies for heart regeneration is controlled delivery.

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Figure 1: Effects of current molecular therapies when administered in the infarct regions of the murine heart.

Katie Vicari


  1. Ptaszek, L.M., Mansour, M., Ruskin, J.N. & Chien, K.R. Lancet 379, 933–942 (2012).

    Article  Google Scholar 

  2. Eulalio, A. et al. Nature 492, 376–381 (2012).

    Article  CAS  Google Scholar 

  3. Jayawardena, T.M. et al. Circ. Res. 110, 1465–1473 (2012).

    Article  CAS  Google Scholar 

  4. Yoo, A.S. et al. Nature 476, 228–231 (2011).

    Article  CAS  Google Scholar 

  5. Hausenloy, D.J. & Yellon, D.M. Cardiovasc. Res. 83, 179–194 (2009).

    Article  CAS  Google Scholar 

  6. Nagai, T. & Komuro, I. Am. J. Physiol. Heart Circ. Physiol. 303, H501–H512 (2012).

    Article  CAS  Google Scholar 

  7. Bock-Marquette, I., Saxena, A., White, M.D., Dimaio, J.M. & Srivastava, D. Nature 432, 466–472 (2004).

    Article  CAS  Google Scholar 

  8. Huang, G.N. et al. Science 338, 1599–1603 (2012).

    Article  CAS  Google Scholar 

  9. Song, K. et al. Nature 485, 599–604 (2012).

    Article  CAS  Google Scholar 

  10. Qian, L. et al. Nature 485, 593–598 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Kenneth R Chien.

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The authors declare no competing financial interests.

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Soh, BS., Wu, H. & Chien, K. Cardiac regenerative medicine 2.0. Nat Biotechnol 31, 209–211 (2013).

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