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Double or nothing on cancer immunotherapy

Engineered T cells expressing two receptors distinguish malignant cells from healthy cells even in the absence of a tumor-specific antigen.

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Figure 1: Strategy for designing T cells to attack tumor cells and spare normal tissues.

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Correspondence to Nicholas P Restifo.

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Hanada, Ki., Restifo, N. Double or nothing on cancer immunotherapy. Nat Biotechnol 31, 33–34 (2013). https://doi.org/10.1038/nbt.2471

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